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Roofing Asphalts, Pitch and UVL Carcinogenesis.

PB83134767

Publication Date	1981
Personal Author	Thayer, P. S.; Menzies, K. T.; von Thuna, P. C.
Page Count	128
Abstract	The tumorigenicity to mouse skin of volatile components of roofing asphalts and coal tar pitches was investigated. Male CD-1 and C3H/H3J-mice were exposed to 25 milligrams per application of ashpalt volatiles or 1.5 to 4.2 milligrams per application of pitch preparations. Treatment was twice weekly for an 18 month period with two temperatures of generation of volatile materials and exposure or lack of exposure to simulated sunlight. The C3H strain of mice was more sensitive to the tumorigenic activity, while simulated sunlight had an inhibitory effect on the rate of appearance of tumors but not on the final tumor incidence. The higher temperature of preparation of the asphalt volatiles resulted in greater tumorigenic activity. The authors conclude that the asphalt volatiles were almost as tumorigenic and carcinogenic to C3H-mice as the pitch volatiles.
Keywords	Environmental surveys Industrial medicine Asphalts Coal tar Exposure Toxicity Inspection Hazardous materials Laboratory animals Neoplasms Malignant neoplasms Toxic substances Occupational safety and health Cancer
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 46G - Plasma Physics
Corporate Authors	Little (Arthur D.), Inc., Cambridge, MA.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198307
Contract Number	PHS-NIOSH-210-78-0035

Roofing Asphalts, Pitch and UVL Carcinogenesis.

Roofing Asphalts, Pitch and UVL Carcinogenesis.
PB83134767

Publication Date	1981
Personal Author	Thayer, P. S.; Menzies, K. T.; von Thuna, P. C.
Page Count	128
Abstract	The tumorigenicity to mouse skin of volatile components of roofing asphalts and coal tar pitches was investigated. Male CD-1 and C3H/H3J-mice were exposed to 25 milligrams per application of ashpalt volatiles or 1.5 to 4.2 milligrams per application of pitch preparations. Treatment was twice weekly for an 18 month period with two temperatures of generation of volatile materials and exposure or lack of exposure to simulated sunlight. The C3H strain of mice was more sensitive to the tumorigenic activity, while simulated sunlight had an inhibitory effect on the rate of appearance of tumors but not on the final tumor incidence. The higher temperature of preparation of the asphalt volatiles resulted in greater tumorigenic activity. The authors conclude that the asphalt volatiles were almost as tumorigenic and carcinogenic to C3H-mice as the pitch volatiles.
Keywords	Environmental surveys Industrial medicine Asphalts Coal tar Exposure Toxicity Inspection Hazardous materials Laboratory animals Neoplasms Malignant neoplasms Toxic substances Occupational safety and health Cancer
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 46G - Plasma Physics
Corporate Authors	Little (Arthur D.), Inc., Cambridge, MA.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198307
Contract Number	PHS-NIOSH-210-78-0035