National Technical Reports Library

The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

Details

Tier II Mutagenic Screening of 13 NIOSH Priority Compounds: Individual Compound Report; Methyl Bromide.

PB83130211

Publication Date	1981
Personal Author	McGregor, D. B.
Page Count	190
Abstract	Methyl-bromide (74839) was subjected to a tier II mutagenic test screening program. Screening included the following assays: unscheduled DNA synthesis (UDS) assay in human diploid fibroblasts with exposures of 3 hours and concentrations up to 70 percent in air; dominant lethal test in male rats and sperm abnormality tests in male mice with exposure to atmospheres containing 20 to 70 parts per million (ppm) methyl-bromide; cytogenetic test in male and female rats with bone marrow cells; and sex linked recessive lethal test in Drosophila-melanogaster with exposure to atmospheres of 20 or 70ppm for 5 hours. There was no increase in UDS in cells treated with methyl-bromide nor was the frequency of aberrant cells increased. There were no effects attributable to methyl-bromide in the dominant lethal test on pregnancy frequency, numbers of corpora lutea graviditatis or implantations, or the frequency of early deaths. Sperm abnormality frequency was not affected and sex linked recessive lethal mutation frequency was not increased as a result of methyl-bromide exposure. The author concludes that methyl-bromide was devoid of genetic effects.
Keywords	Bioassay Toxicology Exposure Fertility Comparison Screenings Physiological effects Rats Laboratory animals Mutagens Bromine organic compounds Methane/bromo Mutagenesis CAS 74-83-9 Medical research Health screening
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57E - Clinical Medicine
Corporate Authors	Inveresk Research International Ltd., Musselburgh (Scotland).; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198305
Contract Number	PHS-NIOSH-21078-0026

Tier II Mutagenic Screening of 13 NIOSH Priority Compounds: Individual Compound Report; Methyl Bromide.

Tier II Mutagenic Screening of 13 NIOSH Priority Compounds: Individual Compound Report; Methyl Bromide.
PB83130211

Publication Date	1981
Personal Author	McGregor, D. B.
Page Count	190
Abstract	Methyl-bromide (74839) was subjected to a tier II mutagenic test screening program. Screening included the following assays: unscheduled DNA synthesis (UDS) assay in human diploid fibroblasts with exposures of 3 hours and concentrations up to 70 percent in air; dominant lethal test in male rats and sperm abnormality tests in male mice with exposure to atmospheres containing 20 to 70 parts per million (ppm) methyl-bromide; cytogenetic test in male and female rats with bone marrow cells; and sex linked recessive lethal test in Drosophila-melanogaster with exposure to atmospheres of 20 or 70ppm for 5 hours. There was no increase in UDS in cells treated with methyl-bromide nor was the frequency of aberrant cells increased. There were no effects attributable to methyl-bromide in the dominant lethal test on pregnancy frequency, numbers of corpora lutea graviditatis or implantations, or the frequency of early deaths. Sperm abnormality frequency was not affected and sex linked recessive lethal mutation frequency was not increased as a result of methyl-bromide exposure. The author concludes that methyl-bromide was devoid of genetic effects.
Keywords	Bioassay Toxicology Exposure Fertility Comparison Screenings Physiological effects Rats Laboratory animals Mutagens Bromine organic compounds Methane/bromo Mutagenesis CAS 74-83-9 Medical research Health screening
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57E - Clinical Medicine
Corporate Authors	Inveresk Research International Ltd., Musselburgh (Scotland).; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198305
Contract Number	PHS-NIOSH-21078-0026