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Carcinogenesis Bioassay of D-Mannitol (CAS No. 69-65-8) in F344/N Rats and B6C3F1 Mice (Feed Study).

PB83129080

Publication Date	1982
Page Count	164
Abstract	A carcinogenesis bioassay of D-mannitol (98%-100% pure), a food and drug additive, was conducted by feeding diets containing 25,000 or 50,000 ppm D-mannitol to groups of 50 F344/N rats and 50 B6C3F1 mice of each sex for 103 weeks. Groups of 50 rats and 50 mice of each sex served as controls. Dilatation of the gastric fundal gland was increased in dosed female rats, retinopathy and cataracts occurred in high-dose males and in low and high dose female rats. Mild nephrosis was observed in dosed mice of either sex. However, under the conditions of this bioassay, D-mannitol was not carcinogenic for F344/N rats or B6C3F1 mice of either sex.
Keywords	Toxicology Food additives Rats Mice Diets Bioassay Laboratory animals Histology Pathology Nephrosis Mannitol Carcinogenesis CAS 69-65-8
Source Agency	National Cancer Institute
NTIS Subject Category	57Y - Toxicology 57E - Clinical Medicine 68G - Environmental Health & Safety
Corporate Authors	National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Technical rept.
NTIS Issue Number	198305

Carcinogenesis Bioassay of D-Mannitol (CAS No. 69-65-8) in F344/N Rats and B6C3F1 Mice (Feed Study).

Carcinogenesis Bioassay of D-Mannitol (CAS No. 69-65-8) in F344/N Rats and B6C3F1 Mice (Feed Study).
PB83129080

Publication Date	1982
Page Count	164
Abstract	A carcinogenesis bioassay of D-mannitol (98%-100% pure), a food and drug additive, was conducted by feeding diets containing 25,000 or 50,000 ppm D-mannitol to groups of 50 F344/N rats and 50 B6C3F1 mice of each sex for 103 weeks. Groups of 50 rats and 50 mice of each sex served as controls. Dilatation of the gastric fundal gland was increased in dosed female rats, retinopathy and cataracts occurred in high-dose males and in low and high dose female rats. Mild nephrosis was observed in dosed mice of either sex. However, under the conditions of this bioassay, D-mannitol was not carcinogenic for F344/N rats or B6C3F1 mice of either sex.
Keywords	Toxicology Food additives Rats Mice Diets Bioassay Laboratory animals Histology Pathology Nephrosis Mannitol Carcinogenesis CAS 69-65-8
Source Agency	National Cancer Institute
NTIS Subject Category	57Y - Toxicology 57E - Clinical Medicine 68G - Environmental Health & Safety
Corporate Authors	National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Technical rept.
NTIS Issue Number	198305