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The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

Details

PB83126607

Publication Date	1981
Personal Author	McGregor, D. B.
Page Count	212
Abstract	The Tier II mutagenic screening of N-methyl-dicyclohexylamine (7560830) is studied. The structure and toxicology of the compound is presented. The chemicals, animals, animal management and atmosphere generation involved with the studies are described. The methods for DNA synthesis assay, cytogenic analysis of rat bone marrow cells, dominant lethal testing, sperm abnormality tests in Drosophila melanogaster and statistical evaluation are discussed. The results of these analyses are presented. The author concludes that N-methyl-dicyclohexylamine has genotoxic properties and can not induce unscheduled DNA synthesis in cultured mammalian cells.
Keywords	Environmental surveys Industrial medicine Exposure Toxicity Inspection Hazardous materials Molecular structure Cyclohexylamine/N-methyl Toxic substances Occupational safety and health CAS 7560-83-0
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety 99 - Chemistry
Corporate Authors	Inveresk Research International Ltd., Musselburgh (Scotland).; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Document Type	Technical Report
NTIS Issue Number	198305
Contract Number	PHS-NIOSH-210-78-0026

Tier II Mutagenic Screening of 13 NIOSH Priority Compounds. Individual Compound Report N-Methyl Dicyclohexylamine.

Tier II Mutagenic Screening of 13 NIOSH Priority Compounds. Individual Compound Report N-Methyl Dicyclohexylamine.
PB83126607

Publication Date	1981
Personal Author	McGregor, D. B.
Page Count	212
Abstract	The Tier II mutagenic screening of N-methyl-dicyclohexylamine (7560830) is studied. The structure and toxicology of the compound is presented. The chemicals, animals, animal management and atmosphere generation involved with the studies are described. The methods for DNA synthesis assay, cytogenic analysis of rat bone marrow cells, dominant lethal testing, sperm abnormality tests in Drosophila melanogaster and statistical evaluation are discussed. The results of these analyses are presented. The author concludes that N-methyl-dicyclohexylamine has genotoxic properties and can not induce unscheduled DNA synthesis in cultured mammalian cells.
Keywords	Environmental surveys Industrial medicine Exposure Toxicity Inspection Hazardous materials Molecular structure Cyclohexylamine/N-methyl Toxic substances Occupational safety and health CAS 7560-83-0
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety 99 - Chemistry
Corporate Authors	Inveresk Research International Ltd., Musselburgh (Scotland).; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Document Type	Technical Report
NTIS Issue Number	198305
Contract Number	PHS-NIOSH-210-78-0026