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Tier II Mutagenic Screening of 13 NIOSH Priority Compounds. Individual Compound Report N-Methyl Dicyclohexylamine.


PB83126607

Publication Date 1981
Personal Author McGregor, D. B.
Page Count 212
Abstract The Tier II mutagenic screening of N-methyl-dicyclohexylamine (7560830) is studied. The structure and toxicology of the compound is presented. The chemicals, animals, animal management and atmosphere generation involved with the studies are described. The methods for DNA synthesis assay, cytogenic analysis of rat bone marrow cells, dominant lethal testing, sperm abnormality tests in Drosophila melanogaster and statistical evaluation are discussed. The results of these analyses are presented. The author concludes that N-methyl-dicyclohexylamine has genotoxic properties and can not induce unscheduled DNA synthesis in cultured mammalian cells.
Keywords
  • Environmental surveys
  • Industrial medicine
  • Exposure
  • Toxicity
  • Inspection
  • Hazardous materials
  • Molecular structure
  • Cyclohexylamine/N-methyl
  • Toxic substances
  • Occupational safety and health
  • CAS 7560-83-0
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
  • 99 - Chemistry
Corporate Authors Inveresk Research International Ltd., Musselburgh (Scotland).; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Document Type Technical Report
NTIS Issue Number 198305
Contract Number
  • PHS-NIOSH-210-78-0026
Tier II Mutagenic Screening of 13 NIOSH Priority Compounds. Individual Compound Report N-Methyl Dicyclohexylamine.
Tier II Mutagenic Screening of 13 NIOSH Priority Compounds. Individual Compound Report N-Methyl Dicyclohexylamine.
PB83126607

  • Environmental surveys
  • Industrial medicine
  • Exposure
  • Toxicity
  • Inspection
  • Hazardous materials
  • Molecular structure
  • Cyclohexylamine/N-methyl
  • Toxic substances
  • Occupational safety and health
  • CAS 7560-83-0
  • National Institute for Occupational Safety and Health
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
  • 99 - Chemistry
  • PHS-NIOSH-210-78-0026
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