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The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

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PB83126474

Publication Date	1982
Page Count	180
Abstract	A carcinogenesis bioassay of C.I Solvent Yellow 14 (94.1% pure), a widely used monoazo dye, was conducted by feeding diets containing 250 or 500 ppm of C.I Solvent Yellow 14 to groups of 50 F344 rats of either sex for 103 weeks. Similar groups of 50 B6C3F1 mice received diets of 500 or 1,000 ppm for 103 weeks. Groups of 50 untreated rats and mice of either sex served as controls. Under the conditions of this bioassay, C.I. Solvent Yellow 14 was carcinogenic in male and female F344/N rats, as evidenced by increased incidences of neoplastic nodules of the liver. C.I. Solvent Yellow 14 was not carcinogenic for B6C3F1 mice of either sex.
Keywords	Dyes Toxicology Bioassay Azo dyes Rats Mice Laboratory animals Ingestion(Biology) Diets Liver Malignant neoplasms Pathology Color index solvent yellow 14 Carcinogenesis Cancer CAS 842-07-9
Source Agency	National Cancer Institute
NTIS Subject Category	57Y - Toxicology 57E - Clinical Medicine 68G - Environmental Health & Safety
Corporate Authors	National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Technical rept.
NTIS Issue Number	198305

Carcinogenesis Bioassay of C. I. Solvent Yellow 14 (CAS No. 842-07-9) in F344/N Rats and B6C3F1 Mice (Feed Study).

Carcinogenesis Bioassay of C. I. Solvent Yellow 14 (CAS No. 842-07-9) in F344/N Rats and B6C3F1 Mice (Feed Study).
PB83126474

Publication Date	1982
Page Count	180
Abstract	A carcinogenesis bioassay of C.I Solvent Yellow 14 (94.1% pure), a widely used monoazo dye, was conducted by feeding diets containing 250 or 500 ppm of C.I Solvent Yellow 14 to groups of 50 F344 rats of either sex for 103 weeks. Similar groups of 50 B6C3F1 mice received diets of 500 or 1,000 ppm for 103 weeks. Groups of 50 untreated rats and mice of either sex served as controls. Under the conditions of this bioassay, C.I. Solvent Yellow 14 was carcinogenic in male and female F344/N rats, as evidenced by increased incidences of neoplastic nodules of the liver. C.I. Solvent Yellow 14 was not carcinogenic for B6C3F1 mice of either sex.
Keywords	Dyes Toxicology Bioassay Azo dyes Rats Mice Laboratory animals Ingestion(Biology) Diets Liver Malignant neoplasms Pathology Color index solvent yellow 14 Carcinogenesis Cancer CAS 842-07-9
Source Agency	National Cancer Institute
NTIS Subject Category	57Y - Toxicology 57E - Clinical Medicine 68G - Environmental Health & Safety
Corporate Authors	National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Technical rept.
NTIS Issue Number	198305