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Tier II Mutagenic Screening of 13 NIOSH Priority Compounds, Individual Compound Report 2-Methoxyethanol.

PB83113407

Publication Date	1980
Personal Author	McGregor, D. B.
Page Count	236
Abstract	The Tier II mutagenic screening of 2-methoxyethanol (109864) is discussed. The properties, human exposure and toxicology of the compound are reviewed. The chemicals, animals, animal management and atmosphere generation, are described. The methods for DNA synthesis assay, cytogenetic analysis of rat bone marrow cells, dominant lethal testing, sperm abnormality analysis, sex linked recessive lethal test and statistical evaluation are discussed. Results of these analysis are presented. The author concludes that 2-methoxyethanol has a profound effect upon male fertility but does not induce chromosomal aberrations in rat bone marrow. Also, it is recommended that more detailed studies of the effects upon testicular cells be conducted to reach an understanding of the dominant lethal test and sperm abnormality test results.
Keywords	Bioassay Toxicology Humans Exposure Fertility Comparison Screenings Physiological effects Laboratory animals Deoxyribonucleic acid Mutagens Mutagenesis Ethanol/methoxy CAS 109-86-4 Medical research Health screening
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57E - Clinical Medicine
Corporate Authors	Inveresk Research International Ltd., Musselburgh (Scotland).; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198303
Contract Number	PHS-NIOSH-210-78-0026

Tier II Mutagenic Screening of 13 NIOSH Priority Compounds, Individual Compound Report 2-Methoxyethanol.

Tier II Mutagenic Screening of 13 NIOSH Priority Compounds, Individual Compound Report 2-Methoxyethanol.
PB83113407

Publication Date	1980
Personal Author	McGregor, D. B.
Page Count	236
Abstract	The Tier II mutagenic screening of 2-methoxyethanol (109864) is discussed. The properties, human exposure and toxicology of the compound are reviewed. The chemicals, animals, animal management and atmosphere generation, are described. The methods for DNA synthesis assay, cytogenetic analysis of rat bone marrow cells, dominant lethal testing, sperm abnormality analysis, sex linked recessive lethal test and statistical evaluation are discussed. Results of these analysis are presented. The author concludes that 2-methoxyethanol has a profound effect upon male fertility but does not induce chromosomal aberrations in rat bone marrow. Also, it is recommended that more detailed studies of the effects upon testicular cells be conducted to reach an understanding of the dominant lethal test and sperm abnormality test results.
Keywords	Bioassay Toxicology Humans Exposure Fertility Comparison Screenings Physiological effects Laboratory animals Deoxyribonucleic acid Mutagens Mutagenesis Ethanol/methoxy CAS 109-86-4 Medical research Health screening
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57E - Clinical Medicine
Corporate Authors	Inveresk Research International Ltd., Musselburgh (Scotland).; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198303
Contract Number	PHS-NIOSH-210-78-0026