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Human Responses to Controlled Exposures of Methylene Chloride Vapor.

PB83109710

Publication Date	1973
Personal Author	Stewart, R. D.; Forster, H. V.; Hake, C. L.; Andre, J.; Lebrun, J.
Page Count	86
Abstract	The behavioral and health effects of exposure to methylene-chloride (75092) (CH2C12) vapor were studied. Eleven male subjects were exposed to 500 parts per million (ppm) of CH2C12 for 7.5 hours per day for 2 days or to concentrations of up to 250ppm for 5 days. Subjects were given a comprehensive medical examination prior to and following exposure. Blood counts and urinalyses were conducted. Alveolar breath samples were taken at various intervals. No deleterious health or behavioral effects were seen at any exposure dose. Carboxyhemoglobin (CoHb) concentrations were consistently increased and averaged over 5 percent at CH2C12 exposures of 250ppm for 7.5 hours. The authors conclude that exposure to methylene-chloride increases CoHb concentrations. They note that this measurement is not a good indicator of CH2C12 exposure because of the unknown presence of carbon-monoxide in industrial environments.
Keywords	Environmental surveys Industrial medicine Chloromethanes Exposure Toxicity Inspection Hazardous materials Vapors Blood analysis Toxic substances Occupational safety and health CAS 75-09-2 Urinalysis Carboxyhemoglobin
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Medical Coll. of Wisconsin, Inc., Milwaukee. Dept. of Environmental Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198301

Human Responses to Controlled Exposures of Methylene Chloride Vapor.

Human Responses to Controlled Exposures of Methylene Chloride Vapor.
PB83109710

Publication Date	1973
Personal Author	Stewart, R. D.; Forster, H. V.; Hake, C. L.; Andre, J.; Lebrun, J.
Page Count	86
Abstract	The behavioral and health effects of exposure to methylene-chloride (75092) (CH2C12) vapor were studied. Eleven male subjects were exposed to 500 parts per million (ppm) of CH2C12 for 7.5 hours per day for 2 days or to concentrations of up to 250ppm for 5 days. Subjects were given a comprehensive medical examination prior to and following exposure. Blood counts and urinalyses were conducted. Alveolar breath samples were taken at various intervals. No deleterious health or behavioral effects were seen at any exposure dose. Carboxyhemoglobin (CoHb) concentrations were consistently increased and averaged over 5 percent at CH2C12 exposures of 250ppm for 7.5 hours. The authors conclude that exposure to methylene-chloride increases CoHb concentrations. They note that this measurement is not a good indicator of CH2C12 exposure because of the unknown presence of carbon-monoxide in industrial environments.
Keywords	Environmental surveys Industrial medicine Chloromethanes Exposure Toxicity Inspection Hazardous materials Vapors Blood analysis Toxic substances Occupational safety and health CAS 75-09-2 Urinalysis Carboxyhemoglobin
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Medical Coll. of Wisconsin, Inc., Milwaukee. Dept. of Environmental Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198301