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Effects of Methyl Butyl Ketone on Peripheral Nerves and Its Mechanism of Action.


PB83105148

Publication Date 1977
Personal Author deJesus, C.; Pleasure, D. F.; Asbury, A. K.; Brown, M. J.; Paradise, C. M.
Page Count 46
Abstract The effects of methyl-n-butyl-ketone (591786) (MBK) and methyl-ethyl-ketone (78933) (MEK) on the peripheral nerves of rats were studied. Wistar-rats inhaled 60 to 1050 parts per million (ppm) of MBK or 1460 to 4740ppm of MEK for 6 hours per day, 5 days per week for 4 to 6 weeks; rats were exposed to MBK until overt signs of neuropathy were evident. Electrophysiological, biochemical, and morphological examinations were performed. No animals exposed to MBK or MEK developed overt neuropathy by 6 weeks. Clinical signs of neuropathy became noticable at 9 to 10 weeks of MBK exposure. All MBK treated rats developed neuropathy by weeks 11 to 13. No neuropathic effects were seen in rats exposed to MEK. The authors conclude that MBK causes neuropathy while MEK does not.
Keywords
  • Nervous system disorders
  • Methyl ethyl ketone
  • Toxicology
  • Rats
  • Laboratory rats
  • Physiological effects
  • Concentration(Biology)
  • Organic solvents
  • Electrophysiologic recording
  • Ketone/butyl-methyl
  • CAS 78-93-3
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57Y - Toxicology
Corporate Authors Yale Univ., New Haven, CT. School of Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes Prepared in cooperation with Pennsylvania Univ., Philadelphia, and Veterans Administration Hospital, West Haven, CT.
Document Type Technical Report
Title Note Final rept.
NTIS Issue Number 198301
Contract Number
  • PHS-CDC-99-76-16
Effects of Methyl Butyl Ketone on Peripheral Nerves and Its Mechanism of Action.
Effects of Methyl Butyl Ketone on Peripheral Nerves and Its Mechanism of Action.
PB83105148

  • Nervous system disorders
  • Methyl ethyl ketone
  • Toxicology
  • Rats
  • Laboratory rats
  • Physiological effects
  • Concentration(Biology)
  • Organic solvents
  • Electrophysiologic recording
  • Ketone/butyl-methyl
  • CAS 78-93-3
  • National Institute for Occupational Safety and Health
  • 57Y - Toxicology
  • PHS-CDC-99-76-16
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