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Effects of Methyl Butyl Ketone on Peripheral Nerves and Its Mechanism of Action.

PB83105148

Publication Date	1977
Personal Author	deJesus, C.; Pleasure, D. F.; Asbury, A. K.; Brown, M. J.; Paradise, C. M.
Page Count	46
Abstract	The effects of methyl-n-butyl-ketone (591786) (MBK) and methyl-ethyl-ketone (78933) (MEK) on the peripheral nerves of rats were studied. Wistar-rats inhaled 60 to 1050 parts per million (ppm) of MBK or 1460 to 4740ppm of MEK for 6 hours per day, 5 days per week for 4 to 6 weeks; rats were exposed to MBK until overt signs of neuropathy were evident. Electrophysiological, biochemical, and morphological examinations were performed. No animals exposed to MBK or MEK developed overt neuropathy by 6 weeks. Clinical signs of neuropathy became noticable at 9 to 10 weeks of MBK exposure. All MBK treated rats developed neuropathy by weeks 11 to 13. No neuropathic effects were seen in rats exposed to MEK. The authors conclude that MBK causes neuropathy while MEK does not.
Keywords	Nervous system disorders Methyl ethyl ketone Toxicology Rats Laboratory rats Physiological effects Concentration(Biology) Organic solvents Electrophysiologic recording Ketone/butyl-methyl CAS 78-93-3
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology
Corporate Authors	Yale Univ., New Haven, CT. School of Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Prepared in cooperation with Pennsylvania Univ., Philadelphia, and Veterans Administration Hospital, West Haven, CT.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198301
Contract Number	PHS-CDC-99-76-16

Effects of Methyl Butyl Ketone on Peripheral Nerves and Its Mechanism of Action.

Effects of Methyl Butyl Ketone on Peripheral Nerves and Its Mechanism of Action.
PB83105148

Publication Date	1977
Personal Author	deJesus, C.; Pleasure, D. F.; Asbury, A. K.; Brown, M. J.; Paradise, C. M.
Page Count	46
Abstract	The effects of methyl-n-butyl-ketone (591786) (MBK) and methyl-ethyl-ketone (78933) (MEK) on the peripheral nerves of rats were studied. Wistar-rats inhaled 60 to 1050 parts per million (ppm) of MBK or 1460 to 4740ppm of MEK for 6 hours per day, 5 days per week for 4 to 6 weeks; rats were exposed to MBK until overt signs of neuropathy were evident. Electrophysiological, biochemical, and morphological examinations were performed. No animals exposed to MBK or MEK developed overt neuropathy by 6 weeks. Clinical signs of neuropathy became noticable at 9 to 10 weeks of MBK exposure. All MBK treated rats developed neuropathy by weeks 11 to 13. No neuropathic effects were seen in rats exposed to MEK. The authors conclude that MBK causes neuropathy while MEK does not.
Keywords	Nervous system disorders Methyl ethyl ketone Toxicology Rats Laboratory rats Physiological effects Concentration(Biology) Organic solvents Electrophysiologic recording Ketone/butyl-methyl CAS 78-93-3
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology
Corporate Authors	Yale Univ., New Haven, CT. School of Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Prepared in cooperation with Pennsylvania Univ., Philadelphia, and Veterans Administration Hospital, West Haven, CT.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198301
Contract Number	PHS-CDC-99-76-16