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Chronic Inhalation Toxicity of 1,2-Dibromoethane in Rats with and without Dietary Disulfiram.


PB82195603

Publication Date 1979
Personal Author Wong, L. C. K.; Winston, J. M.; Hong, C. B.; Hagensen, J.
Page Count 40
Abstract The purpose of this study was to assess the chronic toxicity of inhaled 1,2-dibromoethane in rats exposed to a level of 20 ppm under simulated occupational exposure conditions. The study also included an evaluation of the effects of the addition of disulfiram to the diet upon the chronic toxicity of inhaled 1,2-dibromoethane. In addition, the formalin preserved heads of 315 of the rats from this study were sent to Experimental Pathology Laboratories, Incorporated (EPL), Herndon, Virginia, for the preparation of histologic sections and microscopic evaluation of the nasal cavities.
Keywords
  • Toxicology
  • Malignant neoplasms
  • Respiration
  • Rats
  • Laboratory animals
  • Air pollution
  • Ingestion(Biology)
  • Diets
  • Lethal dosage
  • Bioassay
  • Fumes
  • Fungicides
  • Bromine organic compounds
  • Chemotherapentic agent
  • Ethane/dibromo
  • Air pollution effects(Animals)
  • Disulfiram
  • Carcinogenesis
  • Cancer
  • Synergism
  • CAS 106-93-4
  • CAS 97-77-8
Source Agency
  • Centers for Disease Control Bureau of Laboratories
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57Y - Toxicology
  • 68A - Air Pollution & Control
Corporate Authors Midwest Research Inst., Kansas City, MO.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type Technical Report
NTIS Issue Number 198216
Contract Number
  • PHS-NIOSH-210-76-0131
Chronic Inhalation Toxicity of 1,2-Dibromoethane in Rats with and without Dietary Disulfiram.
Chronic Inhalation Toxicity of 1,2-Dibromoethane in Rats with and without Dietary Disulfiram.
PB82195603

  • Toxicology
  • Malignant neoplasms
  • Respiration
  • Rats
  • Laboratory animals
  • Air pollution
  • Ingestion(Biology)
  • Diets
  • Lethal dosage
  • Bioassay
  • Fumes
  • Fungicides
  • Bromine organic compounds
  • Chemotherapentic agent
  • Ethane/dibromo
  • Air pollution effects(Animals)
  • Disulfiram
  • Carcinogenesis
  • Cancer
  • Synergism
  • CAS 106-93-4
  • CAS 97-77-8
  • Centers for Disease Control Bureau of Laboratories
  • National Institute for Occupational Safety and Health
  • 57Y - Toxicology
  • 68A - Air Pollution & Control
  • PHS-NIOSH-210-76-0131
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