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Chronic Inhalation Toxicity of 1,2-Dibromoethane in Rats with and without Dietary Disulfiram.

PB82195603

Publication Date	1979
Personal Author	Wong, L. C. K.; Winston, J. M.; Hong, C. B.; Hagensen, J.
Page Count	40
Abstract	The purpose of this study was to assess the chronic toxicity of inhaled 1,2-dibromoethane in rats exposed to a level of 20 ppm under simulated occupational exposure conditions. The study also included an evaluation of the effects of the addition of disulfiram to the diet upon the chronic toxicity of inhaled 1,2-dibromoethane. In addition, the formalin preserved heads of 315 of the rats from this study were sent to Experimental Pathology Laboratories, Incorporated (EPL), Herndon, Virginia, for the preparation of histologic sections and microscopic evaluation of the nasal cavities.
Keywords	Toxicology Malignant neoplasms Respiration Rats Laboratory animals Air pollution Ingestion(Biology) Diets Lethal dosage Bioassay Fumes Fungicides Bromine organic compounds Chemotherapentic agent Ethane/dibromo Air pollution effects(Animals) Disulfiram Carcinogenesis Cancer Synergism CAS 106-93-4 CAS 97-77-8
Source Agency	Centers for Disease Control Bureau of Laboratories National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 68A - Air Pollution & Control
Corporate Authors	Midwest Research Inst., Kansas City, MO.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198216
Contract Number	PHS-NIOSH-210-76-0131

Chronic Inhalation Toxicity of 1,2-Dibromoethane in Rats with and without Dietary Disulfiram.

Chronic Inhalation Toxicity of 1,2-Dibromoethane in Rats with and without Dietary Disulfiram.
PB82195603

Publication Date	1979
Personal Author	Wong, L. C. K.; Winston, J. M.; Hong, C. B.; Hagensen, J.
Page Count	40
Abstract	The purpose of this study was to assess the chronic toxicity of inhaled 1,2-dibromoethane in rats exposed to a level of 20 ppm under simulated occupational exposure conditions. The study also included an evaluation of the effects of the addition of disulfiram to the diet upon the chronic toxicity of inhaled 1,2-dibromoethane. In addition, the formalin preserved heads of 315 of the rats from this study were sent to Experimental Pathology Laboratories, Incorporated (EPL), Herndon, Virginia, for the preparation of histologic sections and microscopic evaluation of the nasal cavities.
Keywords	Toxicology Malignant neoplasms Respiration Rats Laboratory animals Air pollution Ingestion(Biology) Diets Lethal dosage Bioassay Fumes Fungicides Bromine organic compounds Chemotherapentic agent Ethane/dibromo Air pollution effects(Animals) Disulfiram Carcinogenesis Cancer Synergism CAS 106-93-4 CAS 97-77-8
Source Agency	Centers for Disease Control Bureau of Laboratories National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 68A - Air Pollution & Control
Corporate Authors	Midwest Research Inst., Kansas City, MO.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198216
Contract Number	PHS-NIOSH-210-76-0131