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Acetone: Development of a Biologic Standard for the Industrial Worker by Breath Analysis.

PB82172917

Publication Date	1975
Personal Author	Stewart, R. D.; Hake, C. L.; Wu, A.; Graff, S. A.; Forster, H. V.
Page Count	92
Abstract	In order to determine physiological responses and develop a practical biological test to indicate the magnitude of industrial exposure to acetone (67641), 20 healthy adults of both sexes were exposed to known concentrations of acetone vapor in a controlled environment chamber. Exposures consisted of both steady, nonfluctuating vapor concentrations and widely fluctuating vapor concentrations. Male subjects were exposed to acetone vapor concentrations of 0, 200, 1000, and 1250 ppm for periods of 3 or 7.5 hr. Blood samples were taken. Various neurological and physiological tests were performed. Highly reproducible breath decay curves were obtained. Minimal variations in range of acetone in breath in identically exposed groups indicated breath analysis to be a rapid method for detection of the magnitude of recent acetone exposure and provides a biologic threshold-limit. Repetitive exposure to the current threshold-limit-value (TLV) of 1000 ppm produced no serious health responses in healthy subjects. Changes observed in the visual evoked response of males given 1250Oppm and the possible effect of 1000 ppm on the menstrual cycle indicate that the current TLV may not afford a substantial safety margin.
Keywords	Industrial hygiene Acetone Concentration(Composition) Physiological effects Responses Ketones Males Organic solvents Tests Vapors Eye(Anatomy) Visual acuity Reproduction(Biology) Sampling Blood analysis Senses Thresholds(Perception) Exposure Occupational safety and health Breath tests Urinalysis Maximum permissible exposure level Air pollution effects(Humans)
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 68A - Air Pollution & Control
Corporate Authors	Medical Coll. of Wisconsin, Inc., Milwaukee. Dept. of Environmental Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198213
Contract Number	PHS-HSM-99-72-84

Acetone: Development of a Biologic Standard for the Industrial Worker by Breath Analysis.

Acetone: Development of a Biologic Standard for the Industrial Worker by Breath Analysis.
PB82172917

Publication Date	1975
Personal Author	Stewart, R. D.; Hake, C. L.; Wu, A.; Graff, S. A.; Forster, H. V.
Page Count	92
Abstract	In order to determine physiological responses and develop a practical biological test to indicate the magnitude of industrial exposure to acetone (67641), 20 healthy adults of both sexes were exposed to known concentrations of acetone vapor in a controlled environment chamber. Exposures consisted of both steady, nonfluctuating vapor concentrations and widely fluctuating vapor concentrations. Male subjects were exposed to acetone vapor concentrations of 0, 200, 1000, and 1250 ppm for periods of 3 or 7.5 hr. Blood samples were taken. Various neurological and physiological tests were performed. Highly reproducible breath decay curves were obtained. Minimal variations in range of acetone in breath in identically exposed groups indicated breath analysis to be a rapid method for detection of the magnitude of recent acetone exposure and provides a biologic threshold-limit. Repetitive exposure to the current threshold-limit-value (TLV) of 1000 ppm produced no serious health responses in healthy subjects. Changes observed in the visual evoked response of males given 1250Oppm and the possible effect of 1000 ppm on the menstrual cycle indicate that the current TLV may not afford a substantial safety margin.
Keywords	Industrial hygiene Acetone Concentration(Composition) Physiological effects Responses Ketones Males Organic solvents Tests Vapors Eye(Anatomy) Visual acuity Reproduction(Biology) Sampling Blood analysis Senses Thresholds(Perception) Exposure Occupational safety and health Breath tests Urinalysis Maximum permissible exposure level Air pollution effects(Humans)
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 68A - Air Pollution & Control
Corporate Authors	Medical Coll. of Wisconsin, Inc., Milwaukee. Dept. of Environmental Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198213
Contract Number	PHS-HSM-99-72-84