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Toulene: Development of a Biologic Standard for the Industrial Worker by Breath Analysis.

PB82154220

Publication Date	1975
Personal Author	Stewart, R. D.; Hake, C. L.; Forster, H. V.; Lebrun, A. J.; Peterson, J. E.
Page Count	138
Abstract	A comprehensive study to determine the biologic threshold-limit-value of toluene (108883) utilizing the breath-analysis decay curve (BADC) was conducted. Twenty healthy adults were exposed to vapor concentrations in an environmentally controlled chamber. The exposure consisted of both steady nonfluctuating concentrations as well as widely fluctuating concentrations. Eleven male subjects were exposed to 0, 20, 50, and 100ppm toluene for 1, 3 or 7.5 hr. Female subjects were exposed to 100ppm for 1, 3 or 7.5 hr. Breath and urine samples were taken. Neurological studies, cardiopulmonary-function tests, and cognitive testing were performed. Subjects exposed to toluene at 100 ppm for 7.5 hr/day, 5 day/wk demonstrated deleterius effects on visual-evoked-response, increased errors in an alertness test and irritation of the nasal-mucosa. Subjects at 100 ppm 3 hr/day, 5 day/wk noted an increase in eye, nose, and throat irritation. Blood-levels were relatively constant at exposures of 50 and 100 ppm. Hippuric acid (495692) excretion increased in a dose-dependent manner. The biologic threshold-limit-value for toluene workers is suggested to be the upper-limit of the range of BADC of those exposed 7.5 hr/day for 5 days.
Keywords	Toxic tolerances Toluene Industrial medicine Aromatic hydrocarbons Concentration(Composition) Exposure Males Females Blood analysis Behavior Tests Standards Vapors Air pollution Air pollution standards Threshold limit value Occupational safety and health Maximum permissible exposure Urinalysis Breath tests CAS 108-88-3 CAS 495-69-2 Hippuric acid
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 68A - Air Pollution & Control
Corporate Authors	Medical Coll. of Wisconsin, Inc., Milwaukee. Dept. of Environmental Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198209
Contract Number	PHS-HSM-99-72-84

Toulene: Development of a Biologic Standard for the Industrial Worker by Breath Analysis.

Toulene: Development of a Biologic Standard for the Industrial Worker by Breath Analysis.
PB82154220

Publication Date	1975
Personal Author	Stewart, R. D.; Hake, C. L.; Forster, H. V.; Lebrun, A. J.; Peterson, J. E.
Page Count	138
Abstract	A comprehensive study to determine the biologic threshold-limit-value of toluene (108883) utilizing the breath-analysis decay curve (BADC) was conducted. Twenty healthy adults were exposed to vapor concentrations in an environmentally controlled chamber. The exposure consisted of both steady nonfluctuating concentrations as well as widely fluctuating concentrations. Eleven male subjects were exposed to 0, 20, 50, and 100ppm toluene for 1, 3 or 7.5 hr. Female subjects were exposed to 100ppm for 1, 3 or 7.5 hr. Breath and urine samples were taken. Neurological studies, cardiopulmonary-function tests, and cognitive testing were performed. Subjects exposed to toluene at 100 ppm for 7.5 hr/day, 5 day/wk demonstrated deleterius effects on visual-evoked-response, increased errors in an alertness test and irritation of the nasal-mucosa. Subjects at 100 ppm 3 hr/day, 5 day/wk noted an increase in eye, nose, and throat irritation. Blood-levels were relatively constant at exposures of 50 and 100 ppm. Hippuric acid (495692) excretion increased in a dose-dependent manner. The biologic threshold-limit-value for toluene workers is suggested to be the upper-limit of the range of BADC of those exposed 7.5 hr/day for 5 days.
Keywords	Toxic tolerances Toluene Industrial medicine Aromatic hydrocarbons Concentration(Composition) Exposure Males Females Blood analysis Behavior Tests Standards Vapors Air pollution Air pollution standards Threshold limit value Occupational safety and health Maximum permissible exposure Urinalysis Breath tests CAS 108-88-3 CAS 495-69-2 Hippuric acid
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 68A - Air Pollution & Control
Corporate Authors	Medical Coll. of Wisconsin, Inc., Milwaukee. Dept. of Environmental Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198209
Contract Number	PHS-HSM-99-72-84