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Toulene: Development of a Biologic Standard for the Industrial Worker by Breath Analysis.


PB82154220

Publication Date 1975
Personal Author Stewart, R. D.; Hake, C. L.; Forster, H. V.; Lebrun, A. J.; Peterson, J. E.
Page Count 138
Abstract A comprehensive study to determine the biologic threshold-limit-value of toluene (108883) utilizing the breath-analysis decay curve (BADC) was conducted. Twenty healthy adults were exposed to vapor concentrations in an environmentally controlled chamber. The exposure consisted of both steady nonfluctuating concentrations as well as widely fluctuating concentrations. Eleven male subjects were exposed to 0, 20, 50, and 100ppm toluene for 1, 3 or 7.5 hr. Female subjects were exposed to 100ppm for 1, 3 or 7.5 hr. Breath and urine samples were taken. Neurological studies, cardiopulmonary-function tests, and cognitive testing were performed. Subjects exposed to toluene at 100 ppm for 7.5 hr/day, 5 day/wk demonstrated deleterius effects on visual-evoked-response, increased errors in an alertness test and irritation of the nasal-mucosa. Subjects at 100 ppm 3 hr/day, 5 day/wk noted an increase in eye, nose, and throat irritation. Blood-levels were relatively constant at exposures of 50 and 100 ppm. Hippuric acid (495692) excretion increased in a dose-dependent manner. The biologic threshold-limit-value for toluene workers is suggested to be the upper-limit of the range of BADC of those exposed 7.5 hr/day for 5 days.
Keywords
  • Toxic tolerances
  • Toluene
  • Industrial medicine
  • Aromatic hydrocarbons
  • Concentration(Composition)
  • Exposure
  • Males
  • Females
  • Blood analysis
  • Behavior
  • Tests
  • Standards
  • Vapors
  • Air pollution
  • Air pollution standards
  • Threshold limit value
  • Occupational safety and health
  • Maximum permissible exposure
  • Urinalysis
  • Breath tests
  • CAS 108-88-3
  • CAS 495-69-2
  • Hippuric acid
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57Y - Toxicology
  • 57U - Public Health & Industrial Medicine
  • 68G - Environmental Health & Safety
  • 68A - Air Pollution & Control
Corporate Authors Medical Coll. of Wisconsin, Inc., Milwaukee. Dept. of Environmental Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type Technical Report
NTIS Issue Number 198209
Contract Number
  • PHS-HSM-99-72-84
Toulene: Development of a Biologic Standard for the Industrial Worker by Breath Analysis.
Toulene: Development of a Biologic Standard for the Industrial Worker by Breath Analysis.
PB82154220

  • Toxic tolerances
  • Toluene
  • Industrial medicine
  • Aromatic hydrocarbons
  • Concentration(Composition)
  • Exposure
  • Males
  • Females
  • Blood analysis
  • Behavior
  • Tests
  • Standards
  • Vapors
  • Air pollution
  • Air pollution standards
  • Threshold limit value
  • Occupational safety and health
  • Maximum permissible exposure
  • Urinalysis
  • Breath tests
  • CAS 108-88-3
  • CAS 495-69-2
  • Hippuric acid
  • National Institute for Occupational Safety and Health
  • 57Y - Toxicology
  • 57U - Public Health & Industrial Medicine
  • 68G - Environmental Health & Safety
  • 68A - Air Pollution & Control
  • PHS-HSM-99-72-84
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