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1,1,1-Trichloroethane: Development of a Biologic Standard for the Industrial Worker by Breath Analysis.

PB82151879

Publication Date	1975
Personal Author	Stewart, R. D.; Hake, C. L.; Wu, A.; Graff, S. A.; Forester, H. V.
Page Count	109
Abstract	A study was conducted to develop a rapid and accurate test to determine the magnitude of industrial exposure to 1,1,1-trichloroethane (1,1,1-T) (115208) and to assess the physiological effects of vapor exposure. Twenty healthy adults of both sexes were exposed to known concentrations of 1,1,1-T in a controlled environment chamber. The exposure consisted of both steady, nonfluctuating vapor concentrations and widely fluctuating concentrations. Ten male subjects were exposed to concentrations of 0, 100, 350, and 500 ppm for periods of 1, 3 or 7.5 hr. Ten female subjects were exposed to 0 and 350 ppm for periods of 1, 3, or 7.5 hr. Blood, urine and breath samples were collected. Neurological studies, pulmonary function tests, and cognitive tests were also performed. Subjects identically exposed for 5 consecutive days had very similar breath decay curves. Postexposure breath analysis is a practical method to determine body burden of 1,1,1-T and so provides a biologic threshold limit measurement for workmen. Repetitive exposure to 350 ppm 1,1,1-T produced responses in health subjects other than objections to the solvent's odor by the majority of female subjects.
Keywords	Toxic tolerances Permissible dosage Industrial medicine Physiological effects Vapors Exposure Humans Concentration(Composition) Behavior Psychological effects Sampling Blood chemical analysis Senses Clinical chemistry Ethane/trichloro Threshold limit values Breath tests Occupational safety and health CAS 115-20-8 Urinalysis
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 68A - Air Pollution & Control
Corporate Authors	Medical Coll. of Wisconsin, Inc., Milwaukee. Dept. of Environmental Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198209
Contract Number	PHS-HSM-99-72-84

1,1,1-Trichloroethane: Development of a Biologic Standard for the Industrial Worker by Breath Analysis.

1,1,1-Trichloroethane: Development of a Biologic Standard for the Industrial Worker by Breath Analysis.
PB82151879

Publication Date	1975
Personal Author	Stewart, R. D.; Hake, C. L.; Wu, A.; Graff, S. A.; Forester, H. V.
Page Count	109
Abstract	A study was conducted to develop a rapid and accurate test to determine the magnitude of industrial exposure to 1,1,1-trichloroethane (1,1,1-T) (115208) and to assess the physiological effects of vapor exposure. Twenty healthy adults of both sexes were exposed to known concentrations of 1,1,1-T in a controlled environment chamber. The exposure consisted of both steady, nonfluctuating vapor concentrations and widely fluctuating concentrations. Ten male subjects were exposed to concentrations of 0, 100, 350, and 500 ppm for periods of 1, 3 or 7.5 hr. Ten female subjects were exposed to 0 and 350 ppm for periods of 1, 3, or 7.5 hr. Blood, urine and breath samples were collected. Neurological studies, pulmonary function tests, and cognitive tests were also performed. Subjects identically exposed for 5 consecutive days had very similar breath decay curves. Postexposure breath analysis is a practical method to determine body burden of 1,1,1-T and so provides a biologic threshold limit measurement for workmen. Repetitive exposure to 350 ppm 1,1,1-T produced responses in health subjects other than objections to the solvent's odor by the majority of female subjects.
Keywords	Toxic tolerances Permissible dosage Industrial medicine Physiological effects Vapors Exposure Humans Concentration(Composition) Behavior Psychological effects Sampling Blood chemical analysis Senses Clinical chemistry Ethane/trichloro Threshold limit values Breath tests Occupational safety and health CAS 115-20-8 Urinalysis
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 68A - Air Pollution & Control
Corporate Authors	Medical Coll. of Wisconsin, Inc., Milwaukee. Dept. of Environmental Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198209
Contract Number	PHS-HSM-99-72-84