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Urinary Metabolites from Controlled Exposures of Humans to Trichloroethylene.

PB82151713

Publication Date	1973
Personal Author	Hake, C. L.; Stewart, R. D.; Peterson, J. E.; Dodd, H. C.
Page Count	28
Abstract	The urinary metabolites of trichloroethylene (TCE) (79016), trichloroethanol (115208) and trichloroacetic acid (76039), were measured after humans had been exposed for controlled periods of time to either 20, 100 or 200ppm of TCE vapor for 5 days per week. The quantity and concentration of each metabolite varied widely during the daily exposures of identical magnitudes. If the excretion of either of these metabolites, or their sum, is to be considered as a measure of exposure, it must be remembered that at the current TLV, and at higher exposures, both the concentration and quantity are affected by previous recent exposures. At the lowest level of exposure studied the effect was lessened, indicating a better clearance of the metabolites on a daily basis. It is the conclusion that the measurement of urinary metabolites is not an ideal method of predicting the magnitude of a human exposure to the vapors of TCE, particularily if the exposure was near or greater than the current TLV.
Keywords	Urine Chemical analysis Industrial hygiene Clinical chemistry Exposure Chlorine organic compounds Metabolism Air pollution Samples Gas chromatography Ethylene/trichloro Ethanol/trichloro Acetic acid/trichloro Occupational safety and health Metabolites Threshold limit values CAS 79-01-6 CAS 115-20-8 CAS 76-03-9 Procedures Acid
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	68G - Environmental Health & Safety 57Y - Toxicology 57D - Clinical Chemistry 99A - Analytical Chemistry
Corporate Authors	Medical Coll. of Wisconsin, Inc., Milwaukee. Dept. of Environmental Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198209
Contract Number	PHS-HSM-99-72-84

Urinary Metabolites from Controlled Exposures of Humans to Trichloroethylene.

Urinary Metabolites from Controlled Exposures of Humans to Trichloroethylene.
PB82151713

Publication Date	1973
Personal Author	Hake, C. L.; Stewart, R. D.; Peterson, J. E.; Dodd, H. C.
Page Count	28
Abstract	The urinary metabolites of trichloroethylene (TCE) (79016), trichloroethanol (115208) and trichloroacetic acid (76039), were measured after humans had been exposed for controlled periods of time to either 20, 100 or 200ppm of TCE vapor for 5 days per week. The quantity and concentration of each metabolite varied widely during the daily exposures of identical magnitudes. If the excretion of either of these metabolites, or their sum, is to be considered as a measure of exposure, it must be remembered that at the current TLV, and at higher exposures, both the concentration and quantity are affected by previous recent exposures. At the lowest level of exposure studied the effect was lessened, indicating a better clearance of the metabolites on a daily basis. It is the conclusion that the measurement of urinary metabolites is not an ideal method of predicting the magnitude of a human exposure to the vapors of TCE, particularily if the exposure was near or greater than the current TLV.
Keywords	Urine Chemical analysis Industrial hygiene Clinical chemistry Exposure Chlorine organic compounds Metabolism Air pollution Samples Gas chromatography Ethylene/trichloro Ethanol/trichloro Acetic acid/trichloro Occupational safety and health Metabolites Threshold limit values CAS 79-01-6 CAS 115-20-8 CAS 76-03-9 Procedures Acid
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	68G - Environmental Health & Safety 57Y - Toxicology 57D - Clinical Chemistry 99A - Analytical Chemistry
Corporate Authors	Medical Coll. of Wisconsin, Inc., Milwaukee. Dept. of Environmental Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198209
Contract Number	PHS-HSM-99-72-84