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Methyl Chloride: Development of a Biologic Standard for the Industrial Worker by Breath Analysis.

PB81167686

Publication Date	1980
Personal Author	Stewart, R. D.; Hake, C. L.; Wu, A.; Graff, S. A.; Forster, H. V.
Page Count	162
Abstract	Blood and breath analyses were used to evaluate methyl chloride (74873) exposure in humans. Adults of both sexes were exposed repetitively on a daily basis to methyl chloride gas in concentrations of 0, 20, 100, and 150 parts per million for 1, 3 and 7.5 hours. Physiological responses were monitored, and blood and alveolar air samples were analyzed for methyl chloride concentrations. Physiological, neurological, behavioral, clinical and medical studies revealed no deleterious effects of the methyl chloride exposures. Three male and one female subject had elevated blood and breath methyl chloride concentrations, while these values for the remaining seven male and eight female subjects were not altered by the exposures. The authors conclude that some individuals are more sensitive to methyl chloride exposure, and recommended that breath monitoring can be used to identify exposed employees with higher body burden of the chemical. They suggest that the physically stressed workers may be adversely affected by repeated exposures to the recommended time weighted average concentration (unreported).
Keywords	Hazardous materials Industrial medicine Environmental surveys Chloromethanes Exposure Toxicity Criteria Inspection Standards Recommendations Industrial hygiene Concentration(Composition) Thresholds(Physiology) Detection Sampling Anesthetics Chlorohydrocarbons Toxic substances Occupational safety and health Air sampling Maximum permissible exposures CAS 74-87-3
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Medical Coll. of Wisconsin, Inc., Milwaukee. Dept. of Microbiology.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198114
Contract Number	PHS-HSM-99-72-84

Methyl Chloride: Development of a Biologic Standard for the Industrial Worker by Breath Analysis.

Methyl Chloride: Development of a Biologic Standard for the Industrial Worker by Breath Analysis.
PB81167686

Publication Date	1980
Personal Author	Stewart, R. D.; Hake, C. L.; Wu, A.; Graff, S. A.; Forster, H. V.
Page Count	162
Abstract	Blood and breath analyses were used to evaluate methyl chloride (74873) exposure in humans. Adults of both sexes were exposed repetitively on a daily basis to methyl chloride gas in concentrations of 0, 20, 100, and 150 parts per million for 1, 3 and 7.5 hours. Physiological responses were monitored, and blood and alveolar air samples were analyzed for methyl chloride concentrations. Physiological, neurological, behavioral, clinical and medical studies revealed no deleterious effects of the methyl chloride exposures. Three male and one female subject had elevated blood and breath methyl chloride concentrations, while these values for the remaining seven male and eight female subjects were not altered by the exposures. The authors conclude that some individuals are more sensitive to methyl chloride exposure, and recommended that breath monitoring can be used to identify exposed employees with higher body burden of the chemical. They suggest that the physically stressed workers may be adversely affected by repeated exposures to the recommended time weighted average concentration (unreported).
Keywords	Hazardous materials Industrial medicine Environmental surveys Chloromethanes Exposure Toxicity Criteria Inspection Standards Recommendations Industrial hygiene Concentration(Composition) Thresholds(Physiology) Detection Sampling Anesthetics Chlorohydrocarbons Toxic substances Occupational safety and health Air sampling Maximum permissible exposures CAS 74-87-3
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Medical Coll. of Wisconsin, Inc., Milwaukee. Dept. of Microbiology.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198114
Contract Number	PHS-HSM-99-72-84