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Acute Inhalation Toxicity of Perfluorodecalin, Octafluorotoluene, and Perfluorohexylsulfurpentafluoride in Rats.

PB81156911

Publication Date	1979
Personal Author	Dilley, J. V.
Page Count	50
Abstract	The toxicity from a 1-hour exposure to vapors of perfluorodecalin, octafluorotoluene, and perfluorohexysulfurpentafluoride was investigated in male and female rats. No toxicity could be demonstrated after exposure to 8647 ppm of perfluorodecalin. The LC50 (with 95 percent confidence limits) for octafluorotoluene was 1141 (1103 to 1197) ppm. The target organ appeared to be the central nervous system, with convulsions terminating in mortality. Two rats surviving high-level exposure exhibited complete loss of function of their hind quarters for the 14-day postexposure period. Kidney damage may also occur in survivors. The LC50 for perfluorohexylsulfurpentafluoride (L-4412) was 4947 ppm (95 percent confidence limits, 4898 to 5007 ppm). The target organ for L-4412 was the lung, and the cause of mortality was acute pulmonary edema. Mortality only occurred 2 to 4 hours after the exposure, suggesting that a metabolite may be formed which causes the acute toxicity. There was also some suggestion of renal injury in the 14-day survivors. Further studies with this compound are suggested.
Keywords	Toxicology Inhalation Laboratory animals Rats Exposure Bioassay Lethal dosage Vapors Males Females Central nervous system Concentration(Composition) Lung Kidney Fluorine organic compounds Toxic substances Sulfur pentafluoride/fluoro-hexyl Toluene/octafluoro Decalin/fluoro Air pollution effects(Animals)
Source Agency	Bureau of Alcohol, Tobacco and Firearms
NTIS Subject Category	57Y - Toxicology 57O - Pathology
Corporate Authors	SRI International, Menlo Park, CA.; Aerospace Corp., Washington, DC.
Supplemental Notes	Sponsored in part by Aerospace Corp., Washington, DC.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198113

Acute Inhalation Toxicity of Perfluorodecalin, Octafluorotoluene, and Perfluorohexylsulfurpentafluoride in Rats.

Acute Inhalation Toxicity of Perfluorodecalin, Octafluorotoluene, and Perfluorohexylsulfurpentafluoride in Rats.
PB81156911

Publication Date	1979
Personal Author	Dilley, J. V.
Page Count	50
Abstract	The toxicity from a 1-hour exposure to vapors of perfluorodecalin, octafluorotoluene, and perfluorohexysulfurpentafluoride was investigated in male and female rats. No toxicity could be demonstrated after exposure to 8647 ppm of perfluorodecalin. The LC50 (with 95 percent confidence limits) for octafluorotoluene was 1141 (1103 to 1197) ppm. The target organ appeared to be the central nervous system, with convulsions terminating in mortality. Two rats surviving high-level exposure exhibited complete loss of function of their hind quarters for the 14-day postexposure period. Kidney damage may also occur in survivors. The LC50 for perfluorohexylsulfurpentafluoride (L-4412) was 4947 ppm (95 percent confidence limits, 4898 to 5007 ppm). The target organ for L-4412 was the lung, and the cause of mortality was acute pulmonary edema. Mortality only occurred 2 to 4 hours after the exposure, suggesting that a metabolite may be formed which causes the acute toxicity. There was also some suggestion of renal injury in the 14-day survivors. Further studies with this compound are suggested.
Keywords	Toxicology Inhalation Laboratory animals Rats Exposure Bioassay Lethal dosage Vapors Males Females Central nervous system Concentration(Composition) Lung Kidney Fluorine organic compounds Toxic substances Sulfur pentafluoride/fluoro-hexyl Toluene/octafluoro Decalin/fluoro Air pollution effects(Animals)
Source Agency	Bureau of Alcohol, Tobacco and Firearms
NTIS Subject Category	57Y - Toxicology 57O - Pathology
Corporate Authors	SRI International, Menlo Park, CA.; Aerospace Corp., Washington, DC.
Supplemental Notes	Sponsored in part by Aerospace Corp., Washington, DC.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198113