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Toxic Evaluation of Inhaled Chlorobenzene (Monochlorobenzene).

PB276623

Publication Date	1977
Personal Author	Dilley, J. V.
Page Count	88
Abstract	Chlorobenzene (monochlorobenzene, benzyl chloride) is extensively used by industry as a solvent and as a chemical intermediate, but relatively little information has been published on its toxicity. The toxicity of inhaled chlorobenzene was evaluated in male rats and rabbits by exposing them to 0, 75, or 250 ppm chlorobenzene vapors for 7 hours daily, 5 days/week, for up to 120 exposure days (24 weeks). Groups of animals from both species were sacrificed after 5 and 11 weeks of treatment and examined for hematology, clinical chemistry, and gross and histopathological changes resulting from the chlorobenzene treatment. A statistical analysis of the data suggests some treatment-related effect on the red cell parameters. Pathological changes were mostly found in rats, where occasional focal lesions in the adrenal cortex, tubular lesions in the kidneys, and congestion in the liver and kidneys suggested a treatment relationship. The subtle changes observed in rats at 75 and 250 ppm suggest that the current maximum permissible concentration for chlorobenzene of 75 ppm may be too high and that 5 to 10 ppm may be a better working level.
Keywords	Chlorobenzenes Toxicology Industrial hygiene Halohydrocarbons Benzenes Vapors Organic solvents Bioassay Toxicity Exposure Dosage Dose rate Rats Rabbits Laboratory animals Hematology Pathology Liver Kidney Adrenal cortex Occupational safety and health Threshold limit values Maximum permissible exposure level Clinical chemistry Histopathology
Source Agency	National Institute for Occupational Safety and Health Stanford Research Institute Stanford University
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Stanford Research Inst., Menlo Park, Calif.; National Inst. for Occupational Safety and Health, Cincinnati, Ohio. Div.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	197809
Contract Number	PHS-210-76-0126

Toxic Evaluation of Inhaled Chlorobenzene (Monochlorobenzene).

Toxic Evaluation of Inhaled Chlorobenzene (Monochlorobenzene).
PB276623

Publication Date	1977
Personal Author	Dilley, J. V.
Page Count	88
Abstract	Chlorobenzene (monochlorobenzene, benzyl chloride) is extensively used by industry as a solvent and as a chemical intermediate, but relatively little information has been published on its toxicity. The toxicity of inhaled chlorobenzene was evaluated in male rats and rabbits by exposing them to 0, 75, or 250 ppm chlorobenzene vapors for 7 hours daily, 5 days/week, for up to 120 exposure days (24 weeks). Groups of animals from both species were sacrificed after 5 and 11 weeks of treatment and examined for hematology, clinical chemistry, and gross and histopathological changes resulting from the chlorobenzene treatment. A statistical analysis of the data suggests some treatment-related effect on the red cell parameters. Pathological changes were mostly found in rats, where occasional focal lesions in the adrenal cortex, tubular lesions in the kidneys, and congestion in the liver and kidneys suggested a treatment relationship. The subtle changes observed in rats at 75 and 250 ppm suggest that the current maximum permissible concentration for chlorobenzene of 75 ppm may be too high and that 5 to 10 ppm may be a better working level.
Keywords	Chlorobenzenes Toxicology Industrial hygiene Halohydrocarbons Benzenes Vapors Organic solvents Bioassay Toxicity Exposure Dosage Dose rate Rats Rabbits Laboratory animals Hematology Pathology Liver Kidney Adrenal cortex Occupational safety and health Threshold limit values Maximum permissible exposure level Clinical chemistry Histopathology
Source Agency	National Institute for Occupational Safety and Health Stanford Research Institute Stanford University
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Stanford Research Inst., Menlo Park, Calif.; National Inst. for Occupational Safety and Health, Cincinnati, Ohio. Div.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	197809
Contract Number	PHS-210-76-0126