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Ocular Ultraviolet Effects from 295 nm to 400 nm in the Rabbit Eye.

PB274780

Publication Date	1977
Page Count	94
Abstract	Pigmented rabbit eyes were irradiated with ultraviolet in 5 nanometer intervals from 290 to 320 nanometers and in 10 nanometer intervals from 325 to 400 nanometers. Ocular tissues were studied with the electron microscope to localize and describe the morphology of the damage. The upper limit of the action spectrum for cornea was established at 320 nanometers. The most efficient waveband for lenticular damage was 300 nanometers which gave a radiant exposure threshold of 0.15 joules per square centimeter. The lenticular radiant exposure threshold produced transient lenticular opacities which disappeared within 24 hours to 2 weeks. Permanent cataracts occurred at radiant exposure levels approximately twice the threshold exposure. Radiant exposures of twice the threshold exposure for the cornea resulted in irreversible corneal damage in the form of stromal haze, stromal opacities, endothelial changes, and anterior uvitis. Preliminary studies on a primate at 300 nanometers gave a corneal threshold and a lens threshold of about 0.01 and 0.12 joules per square centimeter, respectively.
Keywords	Ultraviolet radiation Radiation injuries Eye(Anatomy) Radiation effects Electromagnetic radiation Ionizing radiation Radiation dosage Thresholds(Perception) Histology Pathology Cornea Cataracts Rabbits Laboratory animals Experimental data Experimental design Tables(Data) Electron microscopy
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57V - Radiobiology
Corporate Authors	Houston Univ., Tex. Coll. of Optometry.; National Inst. for Occupational Safety and Health, Cincinnati, Ohio. Div.
Document Type	Technical Report
NTIS Issue Number	197805
Contract Number	PHS-CDC-99-74-12

Ocular Ultraviolet Effects from 295 nm to 400 nm in the Rabbit Eye.

Ocular Ultraviolet Effects from 295 nm to 400 nm in the Rabbit Eye.
PB274780

Publication Date	1977
Page Count	94
Abstract	Pigmented rabbit eyes were irradiated with ultraviolet in 5 nanometer intervals from 290 to 320 nanometers and in 10 nanometer intervals from 325 to 400 nanometers. Ocular tissues were studied with the electron microscope to localize and describe the morphology of the damage. The upper limit of the action spectrum for cornea was established at 320 nanometers. The most efficient waveband for lenticular damage was 300 nanometers which gave a radiant exposure threshold of 0.15 joules per square centimeter. The lenticular radiant exposure threshold produced transient lenticular opacities which disappeared within 24 hours to 2 weeks. Permanent cataracts occurred at radiant exposure levels approximately twice the threshold exposure. Radiant exposures of twice the threshold exposure for the cornea resulted in irreversible corneal damage in the form of stromal haze, stromal opacities, endothelial changes, and anterior uvitis. Preliminary studies on a primate at 300 nanometers gave a corneal threshold and a lens threshold of about 0.01 and 0.12 joules per square centimeter, respectively.
Keywords	Ultraviolet radiation Radiation injuries Eye(Anatomy) Radiation effects Electromagnetic radiation Ionizing radiation Radiation dosage Thresholds(Perception) Histology Pathology Cornea Cataracts Rabbits Laboratory animals Experimental data Experimental design Tables(Data) Electron microscopy
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57V - Radiobiology
Corporate Authors	Houston Univ., Tex. Coll. of Optometry.; National Inst. for Occupational Safety and Health, Cincinnati, Ohio. Div.
Document Type	Technical Report
NTIS Issue Number	197805
Contract Number	PHS-CDC-99-74-12