National Technical Reports Library

The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

Details

Report on Carcinogenesis Bioassay of Chloroform.

PB264018

Publication Date	1976
Personal Author	Page, N. P.; Saffiotti, U.
Page Count	68
Abstract	USP grade chloroform was bioassayed using both sexes of Osborne-Mendel rats and B6C3F1 mice. Two dose levels were administered by oral gavage five times per week for 78 weeks. A decrease in survival rate and weight gain was evident for all treated groups. A significant increase in kidney epithelial tumors was observed in male rats. Highly significant increases in hepatocellular carcinoma were observed in both sexes of mice. Nodular hyperplasia of the liver was observed in many low dose male mice which had not developed hepatocellular carcinoma.
Keywords	Carcinogens Chloroform Bioassay Malignant neoplasms Chlorine organic compounds Rodents Rats Mice Laboratory animals Dosage Dose rate Males Females Body weight Mortality Kidney Liver Lymph nodes Pathology Experimental design Animal models Carcinogenesis Cancer Histopathology
Source Agency	National Institute of Health Office of Cancer Communication
NTIS Subject Category	57Y - Toxicology 57O - Pathology
Corporate Authors	National Cancer Inst., Bethesda, MD. Carcinogenesis Program.
Document Type	Technical Report
Title Note	Technical rept.
NTIS Issue Number	197711

Report on Carcinogenesis Bioassay of Chloroform.

Report on Carcinogenesis Bioassay of Chloroform.
PB264018

Publication Date	1976
Personal Author	Page, N. P.; Saffiotti, U.
Page Count	68
Abstract	USP grade chloroform was bioassayed using both sexes of Osborne-Mendel rats and B6C3F1 mice. Two dose levels were administered by oral gavage five times per week for 78 weeks. A decrease in survival rate and weight gain was evident for all treated groups. A significant increase in kidney epithelial tumors was observed in male rats. Highly significant increases in hepatocellular carcinoma were observed in both sexes of mice. Nodular hyperplasia of the liver was observed in many low dose male mice which had not developed hepatocellular carcinoma.
Keywords	Carcinogens Chloroform Bioassay Malignant neoplasms Chlorine organic compounds Rodents Rats Mice Laboratory animals Dosage Dose rate Males Females Body weight Mortality Kidney Liver Lymph nodes Pathology Experimental design Animal models Carcinogenesis Cancer Histopathology
Source Agency	National Institute of Health Office of Cancer Communication
NTIS Subject Category	57Y - Toxicology 57O - Pathology
Corporate Authors	National Cancer Inst., Bethesda, MD. Carcinogenesis Program.
Document Type	Technical Report
Title Note	Technical rept.
NTIS Issue Number	197711