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Preclinical Toxicologic Evaluation of Maytansine NSC-153858 in Dogs and Monkeys.

PB244628

Publication Date	1975
Personal Author	Thake, D. C.; Naylor, M. W.; Denlinger, R. H.; Guarino, A. M.; Cooney, D. A.
Page Count	260
Abstract	The toxicity of Maytansine (NSC 153858) after intravenous injection in dogs and monkeys was investigated. Clinical signs included anorexia, weight loss, emesis, and diarrhea usually occurring only at the higher dosage levels. Depression of hematologic parameters was evident in animals treated at higher dosage levels from most studies. Leukopenia was slightly more consistent, and in some cases, more severe than depression of RBC, HCT, and HGB parameters, although bone marrow M:E ratios did not reflect this difference. These changes were for the most part of mild or moderate intensity, although marked decreases in WBC did occur at highest dosage levels in Studies III and V-C. Changes in serum enzymes were apparent in animals from all studies. The most consistent change was increase in serum glutamic oxaloacetic transaminase (SGOT) levels immediately following treatment.
Keywords	Antineoplastic agents Toxicity Drugs Pathology Bioassay Laboratory animals Dogs Monkeys Dosage Dose rate Hematology Blood chemical analysis Enzymes Alanines Maytansine Dioxadiazatetracyclo-hexacosapentaene diones
Source Agency	National Cancer Institute
NTIS Subject Category	57Y - Toxicology 57Q - Pharmacology & Pharmacological Chemistry
Corporate Authors	Battelle Columbus Labs., Ohio.; National Cancer Inst., Bethesda, MD. Lab. of Toxicology.
Document Type	Technical Report
Title Note	Final rept. 11 Jun-17 Dec 74.
NTIS Issue Number	197523
Contract Number	N01-CM-43756

Preclinical Toxicologic Evaluation of Maytansine NSC-153858 in Dogs and Monkeys.

Preclinical Toxicologic Evaluation of Maytansine NSC-153858 in Dogs and Monkeys.
PB244628

Publication Date	1975
Personal Author	Thake, D. C.; Naylor, M. W.; Denlinger, R. H.; Guarino, A. M.; Cooney, D. A.
Page Count	260
Abstract	The toxicity of Maytansine (NSC 153858) after intravenous injection in dogs and monkeys was investigated. Clinical signs included anorexia, weight loss, emesis, and diarrhea usually occurring only at the higher dosage levels. Depression of hematologic parameters was evident in animals treated at higher dosage levels from most studies. Leukopenia was slightly more consistent, and in some cases, more severe than depression of RBC, HCT, and HGB parameters, although bone marrow M:E ratios did not reflect this difference. These changes were for the most part of mild or moderate intensity, although marked decreases in WBC did occur at highest dosage levels in Studies III and V-C. Changes in serum enzymes were apparent in animals from all studies. The most consistent change was increase in serum glutamic oxaloacetic transaminase (SGOT) levels immediately following treatment.
Keywords	Antineoplastic agents Toxicity Drugs Pathology Bioassay Laboratory animals Dogs Monkeys Dosage Dose rate Hematology Blood chemical analysis Enzymes Alanines Maytansine Dioxadiazatetracyclo-hexacosapentaene diones
Source Agency	National Cancer Institute
NTIS Subject Category	57Y - Toxicology 57Q - Pharmacology & Pharmacological Chemistry
Corporate Authors	Battelle Columbus Labs., Ohio.; National Cancer Inst., Bethesda, MD. Lab. of Toxicology.
Document Type	Technical Report
Title Note	Final rept. 11 Jun-17 Dec 74.
NTIS Issue Number	197523
Contract Number	N01-CM-43756