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Evaluation of Carcinogenic, Teratogenic, and Mutagenic Activities of Selected Pesticides and Industrial Chemicals. Volume I. Carcinogenic Study.

PB223159

Publication Date	1968
Page Count	428
Abstract	Volume 1 evaluates the carcinogenic potential of 130 commercial pesticides which have been used in part as insecticides, herbicides, and fungicides. Eighteen virgin males and 18 virgin females from hybrid strains (B6AKF1 and B6C3F1) were selected for a test on each compound for each route of administration used. Two types of 18-month studies were carried out: A single subcutaneous injection in 0.05 ml of suspension in nape of neck at 28th day of age; daily oral stomach tube administration from 7th to 28th day of age, and thereafter mixed in feed. No doses above 1,000 mg/kg were studied, except N-Propyl isome at 2,000 mg/kg. All compounds used as positive controls when administered orally were carcinogenic. Only urethane and ethylene imine were carcinogenic by subcutaneous route. Each test compound category had at least one active member with the exception of the Herbicide S-Triazine group. The most predominant tumor was the hepatoma.
Keywords	Carcinogens Pesticides Toxicology Insecticides Herbicides Fungicides Bioassay Mice Malignant neoplasms Neoplasms Liver Lung Reticuloendothelial system DDT Chlorohydrocarbons Thiocarbamates Halohydrocarbons Mutagens Teratogens
Source Agency	Invalid Source Agency Code
NTIS Subject Category	57Y - Toxicology 57E - Clinical Medicine 68G - Environmental Health & Safety 68E - Pesticides Pollution & Control
Corporate Authors	Bionetics Research Labs., Inc., Bethesda, MD.
Document Type	Technical Report
Title Note	Final rept. 1963-Aug 68.
NTIS Issue Number	197321
Contract Number	PH-43-64-57 PH-43-67-735

Evaluation of Carcinogenic, Teratogenic, and Mutagenic Activities of Selected Pesticides and Industrial Chemicals. Volume I. Carcinogenic Study.

Evaluation of Carcinogenic, Teratogenic, and Mutagenic Activities of Selected Pesticides and Industrial Chemicals. Volume I. Carcinogenic Study.
PB223159

Publication Date	1968
Page Count	428
Abstract	Volume 1 evaluates the carcinogenic potential of 130 commercial pesticides which have been used in part as insecticides, herbicides, and fungicides. Eighteen virgin males and 18 virgin females from hybrid strains (B6AKF1 and B6C3F1) were selected for a test on each compound for each route of administration used. Two types of 18-month studies were carried out: A single subcutaneous injection in 0.05 ml of suspension in nape of neck at 28th day of age; daily oral stomach tube administration from 7th to 28th day of age, and thereafter mixed in feed. No doses above 1,000 mg/kg were studied, except N-Propyl isome at 2,000 mg/kg. All compounds used as positive controls when administered orally were carcinogenic. Only urethane and ethylene imine were carcinogenic by subcutaneous route. Each test compound category had at least one active member with the exception of the Herbicide S-Triazine group. The most predominant tumor was the hepatoma.
Keywords	Carcinogens Pesticides Toxicology Insecticides Herbicides Fungicides Bioassay Mice Malignant neoplasms Neoplasms Liver Lung Reticuloendothelial system DDT Chlorohydrocarbons Thiocarbamates Halohydrocarbons Mutagens Teratogens
Source Agency	Invalid Source Agency Code
NTIS Subject Category	57Y - Toxicology 57E - Clinical Medicine 68G - Environmental Health & Safety 68E - Pesticides Pollution & Control
Corporate Authors	Bionetics Research Labs., Inc., Bethesda, MD.
Document Type	Technical Report
Title Note	Final rept. 1963-Aug 68.
NTIS Issue Number	197321
Contract Number	PH-43-64-57 PH-43-67-735