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Evaluation of Carcinogenic, Teratogenic, and Mutagenic Activities of Selected Pesticides and Industrial Chemicals. Volume I. Carcinogenic Study.


PB223159

Publication Date 1968
Page Count 428
Abstract Volume 1 evaluates the carcinogenic potential of 130 commercial pesticides which have been used in part as insecticides, herbicides, and fungicides. Eighteen virgin males and 18 virgin females from hybrid strains (B6AKF1 and B6C3F1) were selected for a test on each compound for each route of administration used. Two types of 18-month studies were carried out: A single subcutaneous injection in 0.05 ml of suspension in nape of neck at 28th day of age; daily oral stomach tube administration from 7th to 28th day of age, and thereafter mixed in feed. No doses above 1,000 mg/kg were studied, except N-Propyl isome at 2,000 mg/kg. All compounds used as positive controls when administered orally were carcinogenic. Only urethane and ethylene imine were carcinogenic by subcutaneous route. Each test compound category had at least one active member with the exception of the Herbicide S-Triazine group. The most predominant tumor was the hepatoma.
Keywords
  • Carcinogens
  • Pesticides
  • Toxicology
  • Insecticides
  • Herbicides
  • Fungicides
  • Bioassay
  • Mice
  • Malignant neoplasms
  • Neoplasms
  • Liver
  • Lung
  • Reticuloendothelial system
  • DDT
  • Chlorohydrocarbons
  • Thiocarbamates
  • Halohydrocarbons
  • Mutagens
  • Teratogens
Source Agency
  • Invalid Source Agency Code
NTIS Subject Category
  • 57Y - Toxicology
  • 57E - Clinical Medicine
  • 68G - Environmental Health & Safety
  • 68E - Pesticides Pollution & Control
Corporate Authors Bionetics Research Labs., Inc., Bethesda, MD.
Document Type Technical Report
Title Note Final rept. 1963-Aug 68.
NTIS Issue Number 197321
Contract Number
  • PH-43-64-57
  • PH-43-67-735
Evaluation of Carcinogenic, Teratogenic, and Mutagenic Activities of Selected Pesticides and Industrial Chemicals. Volume I. Carcinogenic Study.
Evaluation of Carcinogenic, Teratogenic, and Mutagenic Activities of Selected Pesticides and Industrial Chemicals. Volume I. Carcinogenic Study.
PB223159

  • Carcinogens
  • Pesticides
  • Toxicology
  • Insecticides
  • Herbicides
  • Fungicides
  • Bioassay
  • Mice
  • Malignant neoplasms
  • Neoplasms
  • Liver
  • Lung
  • Reticuloendothelial system
  • DDT
  • Chlorohydrocarbons
  • Thiocarbamates
  • Halohydrocarbons
  • Mutagens
  • Teratogens
  • Invalid Source Agency Code
  • 57Y - Toxicology
  • 57E - Clinical Medicine
  • 68G - Environmental Health & Safety
  • 68E - Pesticides Pollution & Control
  • PH-43-64-57
  • PH-43-67-735
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