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Human Reproductive Endocrine Effects of Occupational Solvent Exposure.

PB2018101654

Publication Date	2000
Personal Author	Faustman, E. M.; Luderer, U.; Brodkin, C. A.; Kalman, D.; Morgan, M. S.
Page Count	21
Abstract	Although organic solvents are widely used in many different industries, there is very little data on the effects of exposure to all but a few solvents on male reproductive health. Painters comprise one large occupational group with significant solvent exposure that has not been wellstudied in this regard. We therefore chose to study fertility and reproductive endocrine function in male painters. We assessed time-to-pregnancy (fecundability, an indicator of fertility) using a retrospective cohort design and cross-sectionally measured reproductive hormone concentrations in a group of painters compared to a control group of carpenters and to a group of millwrights with intermediate solvent exposure. Detailed occupational, exposure, medical, and time-topregnancy histories were obtained by telephone interview using previously validated instruments. Blood samples were obtained, and serum luteinizing hormone (LH), follic1estimulating hormone (FSH), and testosterone concentrations were determined by immunoassay. Whole blood lead was also measured. Using Cox regression analysis we found that time-topregnancy was non-significantly longer in the painters and millwrights than the carpenters (relative probability of pregnancy in the painters and millwrights combined compared to the carpenters of 0.76, 95% CI 0.45-1.27). In the multivariate analysis time-to-pregnancy was significantly affected by age of the father at the time of the pregnancy of interest and whether the couple was trying to become pregnant. Using analysis of covariance, LH, FSH, and testosterone concentrations did not differ by exposure group, but LH varied significantly with body mass index and education, and testosterone varied significantly with body mass index. The nonsignificantly reduced fecundability in the two solvent-exposed groups suggests the need for further study of fertility in solvent-exposed men.
Keywords	Endocrine system disorders Male reproductive health Reproductive system disorders Reproductive effects Painters Organic solvents Fertility Hormones Blood sampling Occupational exposure Statistical analysis Epidemiology Exposure limits Toluenes Folliciestimulating Hormone (FSH) Luteinizing Hormone (LH)
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	44G - Environmental & Occupational Factors 57M - Occupational Therapy, Physical Therapy, & Rehabilitation 57A - Anatomy 72F - Statistical Analysis
Corporate Authors	Washington Univ., Seattle. Dept. of Environmental Health.; National Inst. for Occupational Safety and Health, Washington, DC.
Supplemental Notes	See also PB2018-101653.
Document Type	Technical Report
Title Note	Technical rept.
NTIS Issue Number	201901

Human Reproductive Endocrine Effects of Occupational Solvent Exposure.

Human Reproductive Endocrine Effects of Occupational Solvent Exposure.
PB2018101654

Publication Date	2000
Personal Author	Faustman, E. M.; Luderer, U.; Brodkin, C. A.; Kalman, D.; Morgan, M. S.
Page Count	21
Abstract	Although organic solvents are widely used in many different industries, there is very little data on the effects of exposure to all but a few solvents on male reproductive health. Painters comprise one large occupational group with significant solvent exposure that has not been wellstudied in this regard. We therefore chose to study fertility and reproductive endocrine function in male painters. We assessed time-to-pregnancy (fecundability, an indicator of fertility) using a retrospective cohort design and cross-sectionally measured reproductive hormone concentrations in a group of painters compared to a control group of carpenters and to a group of millwrights with intermediate solvent exposure. Detailed occupational, exposure, medical, and time-topregnancy histories were obtained by telephone interview using previously validated instruments. Blood samples were obtained, and serum luteinizing hormone (LH), follic1estimulating hormone (FSH), and testosterone concentrations were determined by immunoassay. Whole blood lead was also measured. Using Cox regression analysis we found that time-topregnancy was non-significantly longer in the painters and millwrights than the carpenters (relative probability of pregnancy in the painters and millwrights combined compared to the carpenters of 0.76, 95% CI 0.45-1.27). In the multivariate analysis time-to-pregnancy was significantly affected by age of the father at the time of the pregnancy of interest and whether the couple was trying to become pregnant. Using analysis of covariance, LH, FSH, and testosterone concentrations did not differ by exposure group, but LH varied significantly with body mass index and education, and testosterone varied significantly with body mass index. The nonsignificantly reduced fecundability in the two solvent-exposed groups suggests the need for further study of fertility in solvent-exposed men.
Keywords	Endocrine system disorders Male reproductive health Reproductive system disorders Reproductive effects Painters Organic solvents Fertility Hormones Blood sampling Occupational exposure Statistical analysis Epidemiology Exposure limits Toluenes Folliciestimulating Hormone (FSH) Luteinizing Hormone (LH)
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	44G - Environmental & Occupational Factors 57M - Occupational Therapy, Physical Therapy, & Rehabilitation 57A - Anatomy 72F - Statistical Analysis
Corporate Authors	Washington Univ., Seattle. Dept. of Environmental Health.; National Inst. for Occupational Safety and Health, Washington, DC.
Supplemental Notes	See also PB2018-101653.
Document Type	Technical Report
Title Note	Technical rept.
NTIS Issue Number	201901