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NTP Research Report on Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives.

PB2018100955

Publication Date	2017
Page Count	80
Abstract	Recent studies report widespread usage or exposure to a variety of chemicals with structural or functional similarity to bisphenol A (BPA), referred to as BPA analogues or derivatives. These have been detected in foodstuffs, house dust, environmental samples, human urine or blood, and thermal paper. Compared to BPA relatively little is known about potential toxicity of these compounds. The objective is to identify and summarize human, animal, and mechanistic toxicity data for 24 BPA analogues of emerging interest to research and regulatory communities. The objective was addressed by two efforts: 1) a systematic review of the available research; and 2) analysis of data available from the high throughput screening programs Tox21/ToxCast. We used systematic review methods to identify relevant studies from the published literature. Over 5,100 literature studies were screened for relevance and 166 were considered relevant. Analyses of the high throughput screening data focused on assessing structural and biological similarity among the BPA analogues and between BPA or estradiol (E2).
Keywords	Biological activity Bisphenol A Structural Analogues Human Urine Blood Environmental samples Mechanistic toxicity data
Source Agency	National Toxicology Program Research Triangle Park
NTIS Subject Category	57A - Anatomy 57V - Radiobiology 57Y - Toxicology
Corporate Authors	National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Research rept.
NTIS Issue Number	201815

NTP Research Report on Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives.

NTP Research Report on Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives.
PB2018100955

Publication Date	2017
Page Count	80
Abstract	Recent studies report widespread usage or exposure to a variety of chemicals with structural or functional similarity to bisphenol A (BPA), referred to as BPA analogues or derivatives. These have been detected in foodstuffs, house dust, environmental samples, human urine or blood, and thermal paper. Compared to BPA relatively little is known about potential toxicity of these compounds. The objective is to identify and summarize human, animal, and mechanistic toxicity data for 24 BPA analogues of emerging interest to research and regulatory communities. The objective was addressed by two efforts: 1) a systematic review of the available research; and 2) analysis of data available from the high throughput screening programs Tox21/ToxCast. We used systematic review methods to identify relevant studies from the published literature. Over 5,100 literature studies were screened for relevance and 166 were considered relevant. Analyses of the high throughput screening data focused on assessing structural and biological similarity among the BPA analogues and between BPA or estradiol (E2).
Keywords	Biological activity Bisphenol A Structural Analogues Human Urine Blood Environmental samples Mechanistic toxicity data
Source Agency	National Toxicology Program Research Triangle Park
NTIS Subject Category	57A - Anatomy 57V - Radiobiology 57Y - Toxicology
Corporate Authors	National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Research rept.
NTIS Issue Number	201815