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NIOSH Skin Notation (SK) Profile: Arsenic and Inorganic Arsenic Containing Compounds (CAS No. 7440-38-2).

PB2018100167

Publication Date	2017
Personal Author	Hudson, N. L.; Dotson, G. S.
Page Count	22
Abstract	There is some indication from toxicokinetic studies that arsenic and its inorganic compounds have measurable, but limited potential to be absorbed through the skin of humans and animals [Dutkiewicz 1977; Wester et al. 1993; Turkall 2003]. The limited availability by the dermal route is consistent with the results of the acute dermal toxicity study identified in animals [Gaines 1960] that indicates that arsenic is not acutely toxic despite its known acute toxicity via other routes. These data are insufficient to adequately evaluate the potential of arsenic and its inorganic compounds to cause systemic effects, including skin cancers, following dermal exposure. Case reports and human studies [Pinto and McGill 1953; Bourrain 1998; Mohamed 1998] and data from animals [Boutwell 1963] indicate that chronic or high-dose dermal exposure to arsenic can result in irritant contact dermatitis. An in vivo animal study using the GPMT did not support the weak skin sensitization data in humans [Wahlberg and Boman 1986]. Therefore, on the basis of these assessments, arsenic is assigned a composite skin notation of SK: DIR (IRR). Table 3 summarizes the skin hazard designations for arsenic previously issued by NIOSH and other organizations. There is not an equivalent dermal designation by the Globally Harmonized System (GHS) for the classification and labeling of chemicals [European Parliament 2008].
Keywords	Toxicology Health effects Arsenic Inorganic arsenic Skin exposure Skin Exposure levels Risk factors Epidemiology Acute toxicity Animal studies Animals Kinetics Chemical kinetics Biological systems Dose response Lethal dose Dermal exposure Skin absorption Exposure assessment Laboratory testing Laboratory animals Contact dermatitis Globally Harmonized System (GHS) Chronic toxicity National Institute for Occupational Safety and Health(NIOSH) CAS No. 7440-38-2
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 44G - Environmental & Occupational Factors 94D - Job Environment
Corporate Authors	National Inst. for Occupational Safety and Health, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	201802

NIOSH Skin Notation (SK) Profile: Arsenic and Inorganic Arsenic Containing Compounds (CAS No. 7440-38-2).

NIOSH Skin Notation (SK) Profile: Arsenic and Inorganic Arsenic Containing Compounds (CAS No. 7440-38-2).
PB2018100167

Publication Date	2017
Personal Author	Hudson, N. L.; Dotson, G. S.
Page Count	22
Abstract	There is some indication from toxicokinetic studies that arsenic and its inorganic compounds have measurable, but limited potential to be absorbed through the skin of humans and animals [Dutkiewicz 1977; Wester et al. 1993; Turkall 2003]. The limited availability by the dermal route is consistent with the results of the acute dermal toxicity study identified in animals [Gaines 1960] that indicates that arsenic is not acutely toxic despite its known acute toxicity via other routes. These data are insufficient to adequately evaluate the potential of arsenic and its inorganic compounds to cause systemic effects, including skin cancers, following dermal exposure. Case reports and human studies [Pinto and McGill 1953; Bourrain 1998; Mohamed 1998] and data from animals [Boutwell 1963] indicate that chronic or high-dose dermal exposure to arsenic can result in irritant contact dermatitis. An in vivo animal study using the GPMT did not support the weak skin sensitization data in humans [Wahlberg and Boman 1986]. Therefore, on the basis of these assessments, arsenic is assigned a composite skin notation of SK: DIR (IRR). Table 3 summarizes the skin hazard designations for arsenic previously issued by NIOSH and other organizations. There is not an equivalent dermal designation by the Globally Harmonized System (GHS) for the classification and labeling of chemicals [European Parliament 2008].
Keywords	Toxicology Health effects Arsenic Inorganic arsenic Skin exposure Skin Exposure levels Risk factors Epidemiology Acute toxicity Animal studies Animals Kinetics Chemical kinetics Biological systems Dose response Lethal dose Dermal exposure Skin absorption Exposure assessment Laboratory testing Laboratory animals Contact dermatitis Globally Harmonized System (GHS) Chronic toxicity National Institute for Occupational Safety and Health(NIOSH) CAS No. 7440-38-2
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 44G - Environmental & Occupational Factors 94D - Job Environment
Corporate Authors	National Inst. for Occupational Safety and Health, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	201802