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Pathophysiological Deficits in the Amygdala After Repeated Isoflurance Exposures.

PB2016104809

Publication Date	2016
Page Count	25
Abstract	After surgery requiring general anesthesia, patients often experience emotional disturbances, but it is unclear if this is due to anesthetic exposure - which may last up to three months after a single surgical intervention or the cumulative effects of repeated exposure to a volatile general anesthetic on anxiety and depression remain unknown. We examined anesthesia exposure and anxiety- or depressive-like alterations as compared to sham control animals. We investigated long-term potentiation (LTP), whole-cell (WC) recordings of GABAergic spontaneous inhibitory post-synaptic currents (sIPSCs) of the basolateral nucleus of the amgydala (BLA), the open field test (OFT) and Porsolt force swim test (FST) in Sprague Dawley rats following a single and repeated isoflurane exposure. This study potentially gives the practicing clinician a better understanding the temporal emotional dysregulation following exposure to general anesthesia.
Keywords	Pathophysiological conditions General anesthesia Amygdala Emotional disturbances Isoflurance exposures Depression (Psychology) Military nurse anesthetists
Source Agency	TriService Nursing Research Program/Uniform Services Univ. of the Health Sciences
NTIS Subject Category	57A - Anatomy 57E - Clinical Medicine 57S - Physiology 57Q - Pharmacology & Pharmacological Chemistry
Corporate Authors	Uniformed Services Univ. of the Health Sciences, Bethesda, MD.; TriService Nursing Research Program, Bethesda, MD.
Document Type	Technical Report
Title Note	Final rept., 15 June 2014 - 01 May 2015.
NTIS Issue Number	201701

Pathophysiological Deficits in the Amygdala After Repeated Isoflurance Exposures.

Pathophysiological Deficits in the Amygdala After Repeated Isoflurance Exposures.
PB2016104809

Publication Date	2016
Page Count	25
Abstract	After surgery requiring general anesthesia, patients often experience emotional disturbances, but it is unclear if this is due to anesthetic exposure - which may last up to three months after a single surgical intervention or the cumulative effects of repeated exposure to a volatile general anesthetic on anxiety and depression remain unknown. We examined anesthesia exposure and anxiety- or depressive-like alterations as compared to sham control animals. We investigated long-term potentiation (LTP), whole-cell (WC) recordings of GABAergic spontaneous inhibitory post-synaptic currents (sIPSCs) of the basolateral nucleus of the amgydala (BLA), the open field test (OFT) and Porsolt force swim test (FST) in Sprague Dawley rats following a single and repeated isoflurane exposure. This study potentially gives the practicing clinician a better understanding the temporal emotional dysregulation following exposure to general anesthesia.
Keywords	Pathophysiological conditions General anesthesia Amygdala Emotional disturbances Isoflurance exposures Depression (Psychology) Military nurse anesthetists
Source Agency	TriService Nursing Research Program/Uniform Services Univ. of the Health Sciences
NTIS Subject Category	57A - Anatomy 57E - Clinical Medicine 57S - Physiology 57Q - Pharmacology & Pharmacological Chemistry
Corporate Authors	Uniformed Services Univ. of the Health Sciences, Bethesda, MD.; TriService Nursing Research Program, Bethesda, MD.
Document Type	Technical Report
Title Note	Final rept., 15 June 2014 - 01 May 2015.
NTIS Issue Number	201701