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Handbook for Conducting a Literature-Based Health Assessment Using OHAT Approach for Systematic Review and Evidence Integration.

PB2016102134

Publication Date	2015
Page Count	98
Abstract	The National Toxicology Program (NTP) and the National Institute of Environmental Health Sciences established the NTP Office of Health Assessment and Translation (OHAT) to serve as an environmental health resource to the public and to regulatory and health agencies (Bucher et al. 2011). This office conducts evaluations to assess the evidence that environmental chemicals, physical substances, or mixtures (collectively referred to as "substances") cause adverse health effects and provides opinions on whether these substances may be of concern, given what is known about current human exposure levels. The opinions are referred to as NTP Level of Concern (LoC) conclusions. OHAT also organizes workshops or state-of-the-science evaluations to address issues of importance in environmental health sciences. OHAT assessments are typically published as OHAT monographs, meeting reports, and/or peer-reviewed journal publications. This document is intended to serve as a handbook, or standard operating procedures (SOP), for the development of systematic review for conducting OHAT evaluations. The SOPs are based on (1) lessons learned from developing protocols for two case studies for implementing systematic review, (2) consideration of public comments received on systematic review during the past two years, and (3) discussions with experts at other organizations and agencies working on applying methods of systematic review to environmental health and toxicology. It provides an overview of the general OHAT evaluation process, including systematic review methodology, and procedures used to integrate evidence and to support conclusions.
Keywords	Health services Health care guideline implementation Literature based discovery Evaluation processes Environmental chemicals Health concerns
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	88A - Operations & Planning 88E - Reference Materials 57E - Clinical Medicine 70B - Management Practice 44N - Health Care Utilization
Corporate Authors	National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Document Type	Technical Report
NTIS Issue Number	201614

Handbook for Conducting a Literature-Based Health Assessment Using OHAT Approach for Systematic Review and Evidence Integration.

Handbook for Conducting a Literature-Based Health Assessment Using OHAT Approach for Systematic Review and Evidence Integration.
PB2016102134

Publication Date	2015
Page Count	98
Abstract	The National Toxicology Program (NTP) and the National Institute of Environmental Health Sciences established the NTP Office of Health Assessment and Translation (OHAT) to serve as an environmental health resource to the public and to regulatory and health agencies (Bucher et al. 2011). This office conducts evaluations to assess the evidence that environmental chemicals, physical substances, or mixtures (collectively referred to as "substances") cause adverse health effects and provides opinions on whether these substances may be of concern, given what is known about current human exposure levels. The opinions are referred to as NTP Level of Concern (LoC) conclusions. OHAT also organizes workshops or state-of-the-science evaluations to address issues of importance in environmental health sciences. OHAT assessments are typically published as OHAT monographs, meeting reports, and/or peer-reviewed journal publications. This document is intended to serve as a handbook, or standard operating procedures (SOP), for the development of systematic review for conducting OHAT evaluations. The SOPs are based on (1) lessons learned from developing protocols for two case studies for implementing systematic review, (2) consideration of public comments received on systematic review during the past two years, and (3) discussions with experts at other organizations and agencies working on applying methods of systematic review to environmental health and toxicology. It provides an overview of the general OHAT evaluation process, including systematic review methodology, and procedures used to integrate evidence and to support conclusions.
Keywords	Health services Health care guideline implementation Literature based discovery Evaluation processes Environmental chemicals Health concerns
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	88A - Operations & Planning 88E - Reference Materials 57E - Clinical Medicine 70B - Management Practice 44N - Health Care Utilization
Corporate Authors	National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Document Type	Technical Report
NTIS Issue Number	201614