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Comparative Resuscitation Measures for Drug Toxicities Utilizing Lipid Emulsions.

PB2015104105

Publication Date	2014
Page Count	33
Abstract	A toxic dose of bupivacaine and antidepressant drugs causes cardiac arrhythmias and ultimately asystole. Resuscitation is difficult and usually unsuccessful. Until recently, cardiopulmonary bypass was the only effectively treatment. Anecdotal evidence suggests that infusion of lipid emulsion may be an effective treatment. No studies have determined the optimal combination of lipid rescue and traditional Advanced Cardiac Life Support (ACLS) therapy for a toxic dose of four selected drugs. The purpose was to determine the optimal combination of lipid rescue and traditional ACLS therapy for treatment overdose of bupivacaine, desipramine, venlafaxine and bupropion.
Keywords	Drug toxicities Lipid emulsions Antidepressant drugs Cardiopulmonary bypass Heart attack Military personal Toxic agent Bupivacaine Cardiac arrhythmias Desipramine Treatment Therapy Resuscitation equipment Advanced Cardiac Life Support (ACLS)
Source Agency	TriService Nursing Research Program/Uniform Services Univ. of the Health Sciences
NTIS Subject Category	57Q - Pharmacology & Pharmacological Chemistry 57E - Clinical Medicine 57X - Surgery 44K - Health Services 44H - Health Care Technology 74E - Logistics, Military Facilities, & Supplies
Corporate Authors	The Geneva Foundation, Tacoma, WA.; TriService Nursing Research Program, Bethesda, MD.
Document Type	Technical Report
Title Note	Final rept., 1 May 2010 - 30 June 2014
NTIS Issue Number	201517
Contract Number	HU0001-10-1-TS02 N10-007

Comparative Resuscitation Measures for Drug Toxicities Utilizing Lipid Emulsions.

Comparative Resuscitation Measures for Drug Toxicities Utilizing Lipid Emulsions.
PB2015104105

Publication Date	2014
Page Count	33
Abstract	A toxic dose of bupivacaine and antidepressant drugs causes cardiac arrhythmias and ultimately asystole. Resuscitation is difficult and usually unsuccessful. Until recently, cardiopulmonary bypass was the only effectively treatment. Anecdotal evidence suggests that infusion of lipid emulsion may be an effective treatment. No studies have determined the optimal combination of lipid rescue and traditional Advanced Cardiac Life Support (ACLS) therapy for a toxic dose of four selected drugs. The purpose was to determine the optimal combination of lipid rescue and traditional ACLS therapy for treatment overdose of bupivacaine, desipramine, venlafaxine and bupropion.
Keywords	Drug toxicities Lipid emulsions Antidepressant drugs Cardiopulmonary bypass Heart attack Military personal Toxic agent Bupivacaine Cardiac arrhythmias Desipramine Treatment Therapy Resuscitation equipment Advanced Cardiac Life Support (ACLS)
Source Agency	TriService Nursing Research Program/Uniform Services Univ. of the Health Sciences
NTIS Subject Category	57Q - Pharmacology & Pharmacological Chemistry 57E - Clinical Medicine 57X - Surgery 44K - Health Services 44H - Health Care Technology 74E - Logistics, Military Facilities, & Supplies
Corporate Authors	The Geneva Foundation, Tacoma, WA.; TriService Nursing Research Program, Bethesda, MD.
Document Type	Technical Report
Title Note	Final rept., 1 May 2010 - 30 June 2014
NTIS Issue Number	201517
Contract Number	HU0001-10-1-TS02 N10-007