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Comparative Resuscitation Measures for Drug Toxicities Utilizing Lipid Emulsions.


PB2015104105

Publication Date 2014
Page Count 33
Abstract A toxic dose of bupivacaine and antidepressant drugs causes cardiac arrhythmias and ultimately asystole. Resuscitation is difficult and usually unsuccessful. Until recently, cardiopulmonary bypass was the only effectively treatment. Anecdotal evidence suggests that infusion of lipid emulsion may be an effective treatment. No studies have determined the optimal combination of lipid rescue and traditional Advanced Cardiac Life Support (ACLS) therapy for a toxic dose of four selected drugs. The purpose was to determine the optimal combination of lipid rescue and traditional ACLS therapy for treatment overdose of bupivacaine, desipramine, venlafaxine and bupropion.
Keywords
  • Drug toxicities
  • Lipid emulsions
  • Antidepressant drugs
  • Cardiopulmonary bypass
  • Heart attack
  • Military personal
  • Toxic agent
  • Bupivacaine
  • Cardiac arrhythmias
  • Desipramine
  • Treatment
  • Therapy
  • Resuscitation equipment
  • Advanced Cardiac Life Support (ACLS)
Source Agency
  • TriService Nursing Research Program/Uniform Services Univ. of the Health Sciences
NTIS Subject Category
  • 57Q - Pharmacology & Pharmacological Chemistry
  • 57E - Clinical Medicine
  • 57X - Surgery
  • 44K - Health Services
  • 44H - Health Care Technology
  • 74E - Logistics, Military Facilities, & Supplies
Corporate Authors The Geneva Foundation, Tacoma, WA.; TriService Nursing Research Program, Bethesda, MD.
Document Type Technical Report
Title Note Final rept., 1 May 2010 - 30 June 2014
NTIS Issue Number 201517
Contract Number
  • HU0001-10-1-TS02
  • N10-007
Comparative Resuscitation Measures for Drug Toxicities Utilizing Lipid Emulsions.
Comparative Resuscitation Measures for Drug Toxicities Utilizing Lipid Emulsions.
PB2015104105

  • Drug toxicities
  • Lipid emulsions
  • Antidepressant drugs
  • Cardiopulmonary bypass
  • Heart attack
  • Military personal
  • Toxic agent
  • Bupivacaine
  • Cardiac arrhythmias
  • Desipramine
  • Treatment
  • Therapy
  • Resuscitation equipment
  • Advanced Cardiac Life Support (ACLS)
  • TriService Nursing Research Program/Uniform Services Univ. of the Health Sciences
  • 57Q - Pharmacology & Pharmacological Chemistry
  • 57E - Clinical Medicine
  • 57X - Surgery
  • 44K - Health Services
  • 44H - Health Care Technology
  • 74E - Logistics, Military Facilities, & Supplies
  • HU0001-10-1-TS02
  • N10-007
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