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Medroxyprogesterone Acetate and Bone Density in Adolescents.

PB2014101774

Publication Date	2005
Personal Author	Shireman, C. L.
Page Count	30
Abstract	The purpose of this research is to determine if the young female's use of DMPA affects bone remodeling. 60 participants, age 14-21, will be followed at zero, three, six, nine and 12 months. Dual energy x-ray absorbtiometry will be used to obtain BMD at the initial visit and at six-month intervals. Blood samples for cross-linked N-telopeptides, estradiol and dihydroepiandrostendione sulfate (DHEAS) will be obtained prior to initiation of DMPA and every 12 weeks prior to each DMPA injection. Exploratory analysis will be used to examine the overall sample and individual pattern of BMD and biochemical variables. Sign tests will be performed in which individual's measures at 6 and 12 months are compared to their baseline level. Descriptive statistics will be used to describe age, race, socioeconomic status, height, weight, body mass index (BMI), calcium intake, physical activity, tobacco and alcohol use. This information will be obtained during a structured interview.
Keywords	Bones Density Adolescents Age Blood samples Body mass index Calcium Females Height Physical activities Race Weight Medroxyprogesterone acetate
Source Agency	TriService Nursing Research Program/Uniform Services Univ. of the Health Sciences
Corporate Authors	National Naval Medical Center, Bethesda, MD.; TriService Nursing Research Program, Bethesda, MD.
Supplemental Notes	Sponsored by TriService Nursing Research Program, Bethesda, MD.
Document Type	Technical Report
NTIS Issue Number	201407

Medroxyprogesterone Acetate and Bone Density in Adolescents.

Medroxyprogesterone Acetate and Bone Density in Adolescents.
PB2014101774

Publication Date	2005
Personal Author	Shireman, C. L.
Page Count	30
Abstract	The purpose of this research is to determine if the young female's use of DMPA affects bone remodeling. 60 participants, age 14-21, will be followed at zero, three, six, nine and 12 months. Dual energy x-ray absorbtiometry will be used to obtain BMD at the initial visit and at six-month intervals. Blood samples for cross-linked N-telopeptides, estradiol and dihydroepiandrostendione sulfate (DHEAS) will be obtained prior to initiation of DMPA and every 12 weeks prior to each DMPA injection. Exploratory analysis will be used to examine the overall sample and individual pattern of BMD and biochemical variables. Sign tests will be performed in which individual's measures at 6 and 12 months are compared to their baseline level. Descriptive statistics will be used to describe age, race, socioeconomic status, height, weight, body mass index (BMI), calcium intake, physical activity, tobacco and alcohol use. This information will be obtained during a structured interview.
Keywords	Bones Density Adolescents Age Blood samples Body mass index Calcium Females Height Physical activities Race Weight Medroxyprogesterone acetate
Source Agency	TriService Nursing Research Program/Uniform Services Univ. of the Health Sciences
Corporate Authors	National Naval Medical Center, Bethesda, MD.; TriService Nursing Research Program, Bethesda, MD.
Supplemental Notes	Sponsored by TriService Nursing Research Program, Bethesda, MD.
Document Type	Technical Report
NTIS Issue Number	201407