National Technical Reports Library

The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

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Encoding of Fear Memory in High and Low Fear Mice.

PB2014101400

Publication Date	2013
Personal Author	Coyner, J.
Page Count	69
Abstract	The purpose of the report is to determine in a mouse model of high and low fear whether a protein expressed in the lateral amygdala is more abundance in the high fear mice following Pavlovian fear conditioning. These data provide important insights into the micro network mechanisms in the barin that may lead to different levels of fear response in individuals. Understanding the circuit level cellular and molecular mechanisms that underlie individual variability in far learning is critical for the development of effective treatment of fear-related illnesses such as PTSD. These data suggest that inhibiting a specific protein in a precise brain region in mice may reduce high fear memory to the level of low fear memory. This information may begin to provide foundations for the understanding and eventual treatment of pathological fear. Using a mouse model of very high and very low fear memory to understand cellular mechanisms in specific brain regions involved in forming fear memories may help identify novel ways to predict individuals at risk for fear related illness. This can potentially lead to targeted treatments for fear-related disorders such as PTSD.
Keywords	Fear Memory Mice Brain Cells(Biology) Illnesses Models Pathology Pharmacology Post traumatic stress disorder(PTSD) Proteins Tests Therapy Amygdala
Source Agency	TriService Nursing Research Program/Uniform Services Univ. of the Health Sciences
Corporate Authors	Henry M. Jackson Foundation, Bethesda, MD.; TriService Nursing Research Program, Bethesda, MD.
Supplemental Notes	Sponsored by TriService Nursing Research Program, Bethesda, MD.
Document Type	Technical Report
NTIS Issue Number	201406

Encoding of Fear Memory in High and Low Fear Mice.

Encoding of Fear Memory in High and Low Fear Mice.
PB2014101400

Publication Date	2013
Personal Author	Coyner, J.
Page Count	69
Abstract	The purpose of the report is to determine in a mouse model of high and low fear whether a protein expressed in the lateral amygdala is more abundance in the high fear mice following Pavlovian fear conditioning. These data provide important insights into the micro network mechanisms in the barin that may lead to different levels of fear response in individuals. Understanding the circuit level cellular and molecular mechanisms that underlie individual variability in far learning is critical for the development of effective treatment of fear-related illnesses such as PTSD. These data suggest that inhibiting a specific protein in a precise brain region in mice may reduce high fear memory to the level of low fear memory. This information may begin to provide foundations for the understanding and eventual treatment of pathological fear. Using a mouse model of very high and very low fear memory to understand cellular mechanisms in specific brain regions involved in forming fear memories may help identify novel ways to predict individuals at risk for fear related illness. This can potentially lead to targeted treatments for fear-related disorders such as PTSD.
Keywords	Fear Memory Mice Brain Cells(Biology) Illnesses Models Pathology Pharmacology Post traumatic stress disorder(PTSD) Proteins Tests Therapy Amygdala
Source Agency	TriService Nursing Research Program/Uniform Services Univ. of the Health Sciences
Corporate Authors	Henry M. Jackson Foundation, Bethesda, MD.; TriService Nursing Research Program, Bethesda, MD.
Supplemental Notes	Sponsored by TriService Nursing Research Program, Bethesda, MD.
Document Type	Technical Report
NTIS Issue Number	201406