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Mixture Effects on the Dermal Absorption of Biocides..

PB2013108433

Publication Date	2009
Personal Author	Baynes, R. E.; Riviere, J. E.; Xia, X. R.; Smith, C.
Page Count	29
Abstract	Workers in the metal-machining industry are frequently reported to develop occupational dermatitis amongst other adverse health effects following exposure to metal-working fluids. The primary focus of this research project was to quantify physicochemical interactions modulating dermal absorption of industrial irritants (e.g., biocides/preservatives) in metal working fluid (MWF) mixtures following dermal exposure. Our laboratory developed a novel membrane-coated fiber (MCF) technique that quantifies not only the partitioning behavior of these toxicologically important solutes but also other solvatochromatic descriptors (e.g., polarity, hydrogen bonding) that more accurately reflect the mechanistic interaction between the irritant, industrial formulation/mixtures, and skin. This approach allowed for quantification of mixture-membrane interactions that can be used as a predictive tool of dermal disposition of irritating biocides or preservatives relevant to worker exposure in the metal machining industry. Another major goal of the study was to evaluate the utility of the membrane-coated fibers (MCF) to capture simple mixture-induced effects and to correlate these changes to dermal permeability using a solvatochromatic approach to quantify physicochemical and biological interactions.
Keywords	Physiological effects Dermatitis Skin irritants Metal machining workers Environmental expsoure Health effects Metalworking fluids Metalworking industry Research project Skin absorption Solutes Toxicity Biocides
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	North Carolina State Univ. at Raleigh. Coll. of Veterinary Medicine.; National Inst. for Occupational Safety and Health, Washington, DC.
Supplemental Notes	See also PB2005-107482. Sponsored by National Inst. for Occupational Safety and Health, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	201319

Mixture Effects on the Dermal Absorption of Biocides..

Mixture Effects on the Dermal Absorption of Biocides..
PB2013108433

Publication Date	2009
Personal Author	Baynes, R. E.; Riviere, J. E.; Xia, X. R.; Smith, C.
Page Count	29
Abstract	Workers in the metal-machining industry are frequently reported to develop occupational dermatitis amongst other adverse health effects following exposure to metal-working fluids. The primary focus of this research project was to quantify physicochemical interactions modulating dermal absorption of industrial irritants (e.g., biocides/preservatives) in metal working fluid (MWF) mixtures following dermal exposure. Our laboratory developed a novel membrane-coated fiber (MCF) technique that quantifies not only the partitioning behavior of these toxicologically important solutes but also other solvatochromatic descriptors (e.g., polarity, hydrogen bonding) that more accurately reflect the mechanistic interaction between the irritant, industrial formulation/mixtures, and skin. This approach allowed for quantification of mixture-membrane interactions that can be used as a predictive tool of dermal disposition of irritating biocides or preservatives relevant to worker exposure in the metal machining industry. Another major goal of the study was to evaluate the utility of the membrane-coated fibers (MCF) to capture simple mixture-induced effects and to correlate these changes to dermal permeability using a solvatochromatic approach to quantify physicochemical and biological interactions.
Keywords	Physiological effects Dermatitis Skin irritants Metal machining workers Environmental expsoure Health effects Metalworking fluids Metalworking industry Research project Skin absorption Solutes Toxicity Biocides
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	North Carolina State Univ. at Raleigh. Coll. of Veterinary Medicine.; National Inst. for Occupational Safety and Health, Washington, DC.
Supplemental Notes	See also PB2005-107482. Sponsored by National Inst. for Occupational Safety and Health, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	201319