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Details

Worker Genetic Susceptibility to Mutagenic Risk (7/1/2001 - 8/30/2010).

PB2013105490

Publication Date	2010
Personal Author	Brandt-Rauf, P. W.
Page Count	11
Abstract	One of the NIOSH's primary research objectives is 'the identification and investigation of the relationships between hazardous working conditions and associated occupational diseases'. A critical part of this process is understanding the complex relationship between workers' genetic make-up and workplace exposures, because it is becoming increasingly important in identifying workers at the greatest risk for developing occupational diseases and for providing possible interventions to reduce that risk and prevent disease. A potential model population for the study of such occupational gene-environment interactions and for the development of related interventions is provided by workers exposed to the carcinogen vinyl chloride (VC), because they represent an important segment of the petrochemical industry workforce and because much is known about the carcinogenic pathways for VC that could account for different health risks in similarly exposed workers. The purpose of this research has been to identify specific biomarkers of acquired and inherited genetic risk in VC-exposed workers that account for different cancer outcomes.
Keywords	Genetics Workers Biomarkers Cancer Carcinogens Diseases Exposure Genes Health hazards Metabolism Neoplastic agents Occupational safety and health Risk factors Statistical data Vinyl chloride Work environment
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57F - Cytology, Genetics, & Molecular Biology 57E - Clinical Medicine 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety
Corporate Authors	Illinois Univ. at Chicago. School of Public Health.; National Inst. for Occupational Safety and Health, Atlanta, GA.
Supplemental Notes	See also PB2019-100551 (9/1/2011 - 8/31/2015). Sponsored by National Inst. for Occupational Safety and Health, Atlanta, GA.
Document Type	Technical Report
NTIS Issue Number	201313

Worker Genetic Susceptibility to Mutagenic Risk (7/1/2001 - 8/30/2010).

Worker Genetic Susceptibility to Mutagenic Risk (7/1/2001 - 8/30/2010).
PB2013105490

Publication Date	2010
Personal Author	Brandt-Rauf, P. W.
Page Count	11
Abstract	One of the NIOSH's primary research objectives is 'the identification and investigation of the relationships between hazardous working conditions and associated occupational diseases'. A critical part of this process is understanding the complex relationship between workers' genetic make-up and workplace exposures, because it is becoming increasingly important in identifying workers at the greatest risk for developing occupational diseases and for providing possible interventions to reduce that risk and prevent disease. A potential model population for the study of such occupational gene-environment interactions and for the development of related interventions is provided by workers exposed to the carcinogen vinyl chloride (VC), because they represent an important segment of the petrochemical industry workforce and because much is known about the carcinogenic pathways for VC that could account for different health risks in similarly exposed workers. The purpose of this research has been to identify specific biomarkers of acquired and inherited genetic risk in VC-exposed workers that account for different cancer outcomes.
Keywords	Genetics Workers Biomarkers Cancer Carcinogens Diseases Exposure Genes Health hazards Metabolism Neoplastic agents Occupational safety and health Risk factors Statistical data Vinyl chloride Work environment
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57F - Cytology, Genetics, & Molecular Biology 57E - Clinical Medicine 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety
Corporate Authors	Illinois Univ. at Chicago. School of Public Health.; National Inst. for Occupational Safety and Health, Atlanta, GA.
Supplemental Notes	See also PB2019-100551 (9/1/2011 - 8/31/2015). Sponsored by National Inst. for Occupational Safety and Health, Atlanta, GA.
Document Type	Technical Report
NTIS Issue Number	201313