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Assessment of Exposure to Ortho-Toluidine and Other Aromatic Amines in a Rubber Chemical Manufacturing Plant. Exposure Assessment Update, Documentation Report.

PB2010103865

Publication Date	2009
Personal Author	Viet, S. M.; Hanley, K. W.; Carreon-Valencia, T.; Ruder, A. M.
Page Count	91
Abstract	In 1991 and 2000, the National Institute for Occupational Safety and Health (NIOSH) published the results of a retrospective cancer incidence study and a mortality study, respectively, of the 1,749 workers employed at a rubber chemical manufacturing plant in NY. These workers were believed to have been occupationally exposed to ortho-toluidine and aniline, suspected bladder carcinogens in animals. Thirteen cases of bladder cancer were observed versus 3.61 expected (standardized incidence ratio (SIR) = 3.6; 90 percent confidence interval (CI) = 2.1-5.7). Among workers considered to have definite exposure (DE) to ortho-toluidine and aniline, the bladder cancer excess risk was 6.5-fold, while for those with possible exposure (PE), the excess risk was nearly 4-fold. The risk of cancer was strongly associated with increased duration of employment in the department where ortho-toluidine was used, with a 27-fold excess risk among workers with 10 or more years of employment. The original exposure characterization for the cohort utilized a surrogate measure of exposure based on departments in which each worker was ever employed, comparing bladder cancer incidence among exposure groups within the cohort. The exposure assignments included: (1) Definitely Exposed (DE), workers who had ever worked in the department where ortho-toluidine and aniline were used, even if they had periods of employment outside of that department; (2) Possibly Exposed (PE), workers who had ever worked in maintenance, shipping, janitorial, or yard work; and (3) Probably Not Exposed (PNE), all other workers who were not likely to have been exposed to ortho-toluidine and aniline.
Keywords	Rubber chemical manufacturing plant New York Exposure assessment update Ortho-toluidine Aniline Worker exposure Incidence study Mortality study National Institute for Occupational Safety and Health (NIOSH)
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	Westat, Inc., Rockville, MD.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH. Industrywide Studies Branch.
Document Type	Technical Report
NTIS Issue Number	201008

Assessment of Exposure to Ortho-Toluidine and Other Aromatic Amines in a Rubber Chemical Manufacturing Plant. Exposure Assessment Update, Documentation Report.

Assessment of Exposure to Ortho-Toluidine and Other Aromatic Amines in a Rubber Chemical Manufacturing Plant. Exposure Assessment Update, Documentation Report.
PB2010103865

Publication Date	2009
Personal Author	Viet, S. M.; Hanley, K. W.; Carreon-Valencia, T.; Ruder, A. M.
Page Count	91
Abstract	In 1991 and 2000, the National Institute for Occupational Safety and Health (NIOSH) published the results of a retrospective cancer incidence study and a mortality study, respectively, of the 1,749 workers employed at a rubber chemical manufacturing plant in NY. These workers were believed to have been occupationally exposed to ortho-toluidine and aniline, suspected bladder carcinogens in animals. Thirteen cases of bladder cancer were observed versus 3.61 expected (standardized incidence ratio (SIR) = 3.6; 90 percent confidence interval (CI) = 2.1-5.7). Among workers considered to have definite exposure (DE) to ortho-toluidine and aniline, the bladder cancer excess risk was 6.5-fold, while for those with possible exposure (PE), the excess risk was nearly 4-fold. The risk of cancer was strongly associated with increased duration of employment in the department where ortho-toluidine was used, with a 27-fold excess risk among workers with 10 or more years of employment. The original exposure characterization for the cohort utilized a surrogate measure of exposure based on departments in which each worker was ever employed, comparing bladder cancer incidence among exposure groups within the cohort. The exposure assignments included: (1) Definitely Exposed (DE), workers who had ever worked in the department where ortho-toluidine and aniline were used, even if they had periods of employment outside of that department; (2) Possibly Exposed (PE), workers who had ever worked in maintenance, shipping, janitorial, or yard work; and (3) Probably Not Exposed (PNE), all other workers who were not likely to have been exposed to ortho-toluidine and aniline.
Keywords	Rubber chemical manufacturing plant New York Exposure assessment update Ortho-toluidine Aniline Worker exposure Incidence study Mortality study National Institute for Occupational Safety and Health (NIOSH)
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	Westat, Inc., Rockville, MD.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH. Industrywide Studies Branch.
Document Type	Technical Report
NTIS Issue Number	201008