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Solvent-Related Functional Brain Abnormalities.

PB2006106720

Publication Date	2005
Personal Author	Morrow, L. A.; Haut, M.; Scott, A.; Kuwabara, H.; Ducatman, A.; Sandstrom, D.
Page Count	14
Abstract	This study investigated central nervous system (eNS) integrity and neuropsychiatric status in a sample of workers with past exposure to solvents while employed in the Railroad (RR) industry. Solvent exposure was evaluated with a structured clinical interview to ascertain an estimate of cumulative lifetime exposure to solvents in the workplace. Exposed workers and a matched group of non-exposed blue collar workers underwent magnetic resonance imaging (MRI) to assess brain structure (e.g., white matter) and positron emission tomography (PET) to asses brain function. A battery of neuropsychological tests was also administered, as well as indices to assess psychiatric status. Exposed workers were selected from a sample of over 250 workers who had been seen in the Occupational and Environmental Health Clinic at the West Virginia University School of Medicine between 1995 and 2003. The subjects in the exposed group had been employed in the RR industry and had been exposed to solvents for at least 10 years.
Keywords	Neuropsychiatry Central nervous system Solvents Railroad industry Occupational exposure Toxic substances Toxicity Interviews Magnetic resonance imaging Psychiatric status Neuropsychological tests Exposure Brain abnormalities Positron emission tomography (PET)
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	Pittsburgh Univ., PA. School of Medicine.; National Inst. for Occupational Safety and Health, Washington, DC.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	200613

Solvent-Related Functional Brain Abnormalities.

Solvent-Related Functional Brain Abnormalities.
PB2006106720

Publication Date	2005
Personal Author	Morrow, L. A.; Haut, M.; Scott, A.; Kuwabara, H.; Ducatman, A.; Sandstrom, D.
Page Count	14
Abstract	This study investigated central nervous system (eNS) integrity and neuropsychiatric status in a sample of workers with past exposure to solvents while employed in the Railroad (RR) industry. Solvent exposure was evaluated with a structured clinical interview to ascertain an estimate of cumulative lifetime exposure to solvents in the workplace. Exposed workers and a matched group of non-exposed blue collar workers underwent magnetic resonance imaging (MRI) to assess brain structure (e.g., white matter) and positron emission tomography (PET) to asses brain function. A battery of neuropsychological tests was also administered, as well as indices to assess psychiatric status. Exposed workers were selected from a sample of over 250 workers who had been seen in the Occupational and Environmental Health Clinic at the West Virginia University School of Medicine between 1995 and 2003. The subjects in the exposed group had been employed in the RR industry and had been exposed to solvents for at least 10 years.
Keywords	Neuropsychiatry Central nervous system Solvents Railroad industry Occupational exposure Toxic substances Toxicity Interviews Magnetic resonance imaging Psychiatric status Neuropsychological tests Exposure Brain abnormalities Positron emission tomography (PET)
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	Pittsburgh Univ., PA. School of Medicine.; National Inst. for Occupational Safety and Health, Washington, DC.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	200613