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Irritant-Induced Asthma: Epidemiology and Pathogenesis.

PB2005105203

Publication Date	2005
Personal Author	Malo, J. L.; Gautrin, D.; Martin, J.
Page Count	60
Abstract	It has been recently recognized that exposure to irritant materials can cause asthma, a type of asthma called Irritant-Induced asthma (IrIA). One of the most dramatic manifestations of this condition was the bronchopulmonary disease that occurred in the survivors of the World Trade Center. When this syndrome occurs at work, it is a type of occupational asthma. The general aim of this proposal was to explore the following questions related to IrIA from both epidemiological and physiopathological approaches: (1) Do single irritant exposures (Reactive Airways Dysfunction Syndrome-RADS--) and multiple irritant exposures (IrIA) result in equivalent consequences for airway structure and function; (2) Are baseline characteristics (atopy, airway caliber and responsiveness) relevant to susceptibility of developing IrIA and RADS.
Keywords	Asthma Epidemiology Pathogenesis Respiratory diseases Occupational exposure Irritant materials Bronchopulmonary diseases Chlorine Smoking Nasal symptoms Air pollution effects(Humans) Airway resistance Risk Inhalations Lungs Irritant-Induced Asthma(IrIA) Reactive Airways Dysfunction Syndrome(RADS)
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	Sacre Coeur Hospital, Montreal (Canada).; McGill Univ., Montreal (Quebec). Meakins-Christie Labs.; National Inst. for Occupational Safety and Health, Washington, DC.
Supplemental Notes	Prepared in cooperation with McGill Univ., Montreal (Quebec). Meakins-Christie Labs. Sponsored by National Inst. for Occupational Safety and Health, Washington, DC.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	200517
Contract Number	NIOSH-5-RO1-OH-004058-03

Irritant-Induced Asthma: Epidemiology and Pathogenesis.

Irritant-Induced Asthma: Epidemiology and Pathogenesis.
PB2005105203

Publication Date	2005
Personal Author	Malo, J. L.; Gautrin, D.; Martin, J.
Page Count	60
Abstract	It has been recently recognized that exposure to irritant materials can cause asthma, a type of asthma called Irritant-Induced asthma (IrIA). One of the most dramatic manifestations of this condition was the bronchopulmonary disease that occurred in the survivors of the World Trade Center. When this syndrome occurs at work, it is a type of occupational asthma. The general aim of this proposal was to explore the following questions related to IrIA from both epidemiological and physiopathological approaches: (1) Do single irritant exposures (Reactive Airways Dysfunction Syndrome-RADS--) and multiple irritant exposures (IrIA) result in equivalent consequences for airway structure and function; (2) Are baseline characteristics (atopy, airway caliber and responsiveness) relevant to susceptibility of developing IrIA and RADS.
Keywords	Asthma Epidemiology Pathogenesis Respiratory diseases Occupational exposure Irritant materials Bronchopulmonary diseases Chlorine Smoking Nasal symptoms Air pollution effects(Humans) Airway resistance Risk Inhalations Lungs Irritant-Induced Asthma(IrIA) Reactive Airways Dysfunction Syndrome(RADS)
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	Sacre Coeur Hospital, Montreal (Canada).; McGill Univ., Montreal (Quebec). Meakins-Christie Labs.; National Inst. for Occupational Safety and Health, Washington, DC.
Supplemental Notes	Prepared in cooperation with McGill Univ., Montreal (Quebec). Meakins-Christie Labs. Sponsored by National Inst. for Occupational Safety and Health, Washington, DC.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	200517
Contract Number	NIOSH-5-RO1-OH-004058-03