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Quantitating Absorption of Complex Chemical Mixtures.

PB2005101509

Publication Date	2004
Personal Author	Riviere, J. E.
Page Count	32
Abstract	A primary route of occupational exposure to toxic chemicals is often through the skin. Exposure to complex mixtures of chemicals is the norm in most of these settings. Although the mechanism of absorption of a single chemical has been well studied, effects of co-administered chemicals on absorption of a systemic toxicant may ultimately determine whether this potential toxicity is ever realized. Estimating exposure for risk assessment purposes under this scenario is difficult, as available databases are based on single chemical exposure. Our group has previously studied the nature of chemical interactions within a mixture that could modulate absorption across the skin. The objective of this present grant was to extend the analysis of chemical mixture interactions that affect percutaneous absorption to define the physical chemical characteristics of the mixture that allow significant mixture interactions to be detected.
Keywords	Chemicals Skin absorption Toxicity Absorption Occupational exposure Characteristics Interactions Permeability Chemical properties Environmental exposure Chemical mixtures
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	North Carolina State Univ. at Raleigh. Coll. of Veterinary Medicine.; National Inst. for Occupational Safety and Health, Washington, DC.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	200508

Quantitating Absorption of Complex Chemical Mixtures.

Quantitating Absorption of Complex Chemical Mixtures.
PB2005101509

Publication Date	2004
Personal Author	Riviere, J. E.
Page Count	32
Abstract	A primary route of occupational exposure to toxic chemicals is often through the skin. Exposure to complex mixtures of chemicals is the norm in most of these settings. Although the mechanism of absorption of a single chemical has been well studied, effects of co-administered chemicals on absorption of a systemic toxicant may ultimately determine whether this potential toxicity is ever realized. Estimating exposure for risk assessment purposes under this scenario is difficult, as available databases are based on single chemical exposure. Our group has previously studied the nature of chemical interactions within a mixture that could modulate absorption across the skin. The objective of this present grant was to extend the analysis of chemical mixture interactions that affect percutaneous absorption to define the physical chemical characteristics of the mixture that allow significant mixture interactions to be detected.
Keywords	Chemicals Skin absorption Toxicity Absorption Occupational exposure Characteristics Interactions Permeability Chemical properties Environmental exposure Chemical mixtures
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	North Carolina State Univ. at Raleigh. Coll. of Veterinary Medicine.; National Inst. for Occupational Safety and Health, Washington, DC.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	200508