Publication Date |
2004 |
Personal Author |
Fiedler, N.; Kipen, H.; Lioy, P.; Zhang, J. |
Page Count |
104 |
Abstract |
Epidemiologic investigations of building-related health complaints document that volatile organic compounds (VOCs), stressors, and individual characteristics (e.g. female gender) contribute to the reported non-specific symptoms. The purpose of the proposed study was to determine the effects of a psychological stressor and the individual variables, negative affect and odor intolerance, on responses of women to a mixture of volatile organic compounds with and without ozone. One hundred and thirty health women (mean age= 27.2 years; mean education=15 years) participated in a 2 (Negative Affect-high and low) x 9 (Odor Intolerance-high and low) x 2 (Stressor) x 3 (Exposures: masked clean air (MCA), VOCs, VOCs with ozone (VOC + O)) repeated measures design. All subjects completed each exposure condition. One-half of the subjects were randomly assigned to exposure conditions with the stressor while the remaining subjects completed the exposures without the stressor. During each 3 hour exposure condition, health effects measured before, during and after exposure included: symptom questionnaires, neurobehavioral performance, salivary cortisol, nasal inflammation (PMN, albumin, IL-6, IL-8), and lung function (FEV 1). Secondary stable products of the ozone-VOC reaction were measured during the VOCs + O sessions only. |
Keywords |
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Source Agency |
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Corporate Authors |
Robert Wood Johnson Medical School, Piscataway, NJ.; National Inst. for Occupational Safety and Health, Washington, DC. |
Supplemental Notes |
Sponsored by National Inst. for Occupational Safety and Health, Washington, DC. |
Document Type |
Technical Report |
NTIS Issue Number |
200504 |