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Health Effects of Exposures to VOC's. Ozone and Stress.


PB2005100331

Publication Date 2004
Personal Author Fiedler, N.; Kipen, H.; Lioy, P.; Zhang, J.
Page Count 104
Abstract Epidemiologic investigations of building-related health complaints document that volatile organic compounds (VOCs), stressors, and individual characteristics (e.g. female gender) contribute to the reported non-specific symptoms. The purpose of the proposed study was to determine the effects of a psychological stressor and the individual variables, negative affect and odor intolerance, on responses of women to a mixture of volatile organic compounds with and without ozone. One hundred and thirty health women (mean age= 27.2 years; mean education=15 years) participated in a 2 (Negative Affect-high and low) x 9 (Odor Intolerance-high and low) x 2 (Stressor) x 3 (Exposures: masked clean air (MCA), VOCs, VOCs with ozone (VOC + O)) repeated measures design. All subjects completed each exposure condition. One-half of the subjects were randomly assigned to exposure conditions with the stressor while the remaining subjects completed the exposures without the stressor. During each 3 hour exposure condition, health effects measured before, during and after exposure included: symptom questionnaires, neurobehavioral performance, salivary cortisol, nasal inflammation (PMN, albumin, IL-6, IL-8), and lung function (FEV 1). Secondary stable products of the ozone-VOC reaction were measured during the VOCs + O sessions only.
Keywords
  • Health effects
  • Women
  • Stresses
  • Odors
  • Ozone
  • Buildings
  • Environmental exposure
  • Questionnaires
  • Epidemiology
  • Air quality
  • Indoor air pollution
  • Volatile organic compounds
  • Neurobehavioral performance
  • Salivary cortisol
  • Nasal inflammation
  • Lung function
Source Agency
  • National Institute for Occupational Safety and Health
Corporate Authors Robert Wood Johnson Medical School, Piscataway, NJ.; National Inst. for Occupational Safety and Health, Washington, DC.
Supplemental Notes Sponsored by National Inst. for Occupational Safety and Health, Washington, DC.
Document Type Technical Report
NTIS Issue Number 200504
Health Effects of Exposures to VOC's. Ozone and Stress.
Health Effects of Exposures to VOC's. Ozone and Stress.
PB2005100331

  • Health effects
  • Women
  • Stresses
  • Odors
  • Ozone
  • Buildings
  • Environmental exposure
  • Questionnaires
  • Epidemiology
  • Air quality
  • Indoor air pollution
  • Volatile organic compounds
  • Neurobehavioral performance
  • Salivary cortisol
  • Nasal inflammation
  • Lung function
  • National Institute for Occupational Safety and Health
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