| Publication Date |
2004 |
| Personal Author |
Brodkin, C. A.; Checkoway, H.; Bushley, A.; Stover, B.; McDonald, G.; Lee, S. |
| Page Count |
16 |
| Abstract |
The purpose of this investigation was to address the following Study Aims: 1) Determining if changes in hepatic parenchymal echogenicity relation to routine hepatic transaminase levels-- occur in solvent exposed painters compared to a referent group of less exposed carpenters. 2) Determining whether elevations in pro-collagen biomarkers of fibrosis and fibrogenesis occur in painters compared to referents. 3) Determining whether elevations in serum bile acids occur in painters compared with the referent group, and 4) Determining whether a dose-response relationship exists between hepatic surveillance end-points and cumulative or subacute exposure to solvents. Conclusion: The significant exposure-response relationship between career cumulative exposure to mixed solvents and hepatic GGT levels supports a primary cholestatic effect of solvents, with an associated trend for hepatic parenchymal changes on ultrasonography. The absence of consistent elevations in cytokine biomarkers of fibrosis suggests that these ultrasonographic findings represent steatosis rather than fibrosis. The cholestatic hepatic effects observed in this study appear to be most prominent in industrial painters, a group with high exposure to mixed solvents. |
| Keywords |
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| Source Agency |
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| Corporate Authors |
Washington Univ., Seattle.; Occupational Safety and Health Administration, Washington, DC. |
| Supplemental Notes |
Sponsored by Occupational Safety and Health Administration, Washington, DC. |
| Document Type |
Technical Report |
| NTIS Issue Number |
200426 |
