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Validity of Computerized Testing in Toxic Encephalopathy, Final Performance Report.


PB2003104584

Publication Date 1999
Page Count 36
Abstract The computer-assisted Neurobehavioral Evaluation System (NES) test battery was developed for the purpose of detecting brain dysfunction resulting from exposure to neurotoxicants. The NES tests are derived from standard neuropsychological tests that have been well characterized in terms of brain-behavior relationships. The purpose of this study was to assess the validity of the updated NES test battery in patients diagnosed with toxicant encephalopathy (TE) either due to exposure to lead or to mixed solvents to improve the interpretation of NES test performance in research studies and clinical evaluations examining central nervous system (CNS) function and neurotoxicant exposure. Performance on a hybrid NES2/3 test battery, consisting of several NES2 and the above listed five NES3 tests, by persons diagnosed with toxicant encephalopathy (TE) was compared to that of controls to determine if performance differences reflect a priori hypothesized brain-behavior relationships. Performance on the NES tests also was correlated with performance on the analogous traditional tests.
Keywords
  • Brain dysfunction
  • Neurotoxicants
  • Computer-assisted
  • Neuropsychological tests
  • Brain-behavior relationships
  • Exposure
  • Neurobehavioral effects
  • Validation
  • Central nervous system
  • Neurobehavioral evaluation system
  • Test batteries
  • Toxicant encephalopathy
Source Agency
  • National Institute for Occupational Safety and Health
Corporate Authors Boston Univ., MA. School of Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type Technical Report
Title Note Rept. for 30 Sep 95-29 Sep 98.
NTIS Issue Number 200320
Validity of Computerized Testing in Toxic Encephalopathy, Final Performance Report.
Validity of Computerized Testing in Toxic Encephalopathy, Final Performance Report.
PB2003104584

  • Brain dysfunction
  • Neurotoxicants
  • Computer-assisted
  • Neuropsychological tests
  • Brain-behavior relationships
  • Exposure
  • Neurobehavioral effects
  • Validation
  • Central nervous system
  • Neurobehavioral evaluation system
  • Test batteries
  • Toxicant encephalopathy
  • National Institute for Occupational Safety and Health
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