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Validity of Computerized Testing in Toxic Encephalopathy, Final Performance Report.

PB2003104584

Publication Date	1999
Page Count	36
Abstract	The computer-assisted Neurobehavioral Evaluation System (NES) test battery was developed for the purpose of detecting brain dysfunction resulting from exposure to neurotoxicants. The NES tests are derived from standard neuropsychological tests that have been well characterized in terms of brain-behavior relationships. The purpose of this study was to assess the validity of the updated NES test battery in patients diagnosed with toxicant encephalopathy (TE) either due to exposure to lead or to mixed solvents to improve the interpretation of NES test performance in research studies and clinical evaluations examining central nervous system (CNS) function and neurotoxicant exposure. Performance on a hybrid NES2/3 test battery, consisting of several NES2 and the above listed five NES3 tests, by persons diagnosed with toxicant encephalopathy (TE) was compared to that of controls to determine if performance differences reflect a priori hypothesized brain-behavior relationships. Performance on the NES tests also was correlated with performance on the analogous traditional tests.
Keywords	Brain dysfunction Neurotoxicants Computer-assisted Neuropsychological tests Brain-behavior relationships Exposure Neurobehavioral effects Validation Central nervous system Neurobehavioral evaluation system Test batteries Toxicant encephalopathy
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	Boston Univ., MA. School of Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Rept. for 30 Sep 95-29 Sep 98.
NTIS Issue Number	200320

Validity of Computerized Testing in Toxic Encephalopathy, Final Performance Report.

Validity of Computerized Testing in Toxic Encephalopathy, Final Performance Report.
PB2003104584

Publication Date	1999
Page Count	36
Abstract	The computer-assisted Neurobehavioral Evaluation System (NES) test battery was developed for the purpose of detecting brain dysfunction resulting from exposure to neurotoxicants. The NES tests are derived from standard neuropsychological tests that have been well characterized in terms of brain-behavior relationships. The purpose of this study was to assess the validity of the updated NES test battery in patients diagnosed with toxicant encephalopathy (TE) either due to exposure to lead or to mixed solvents to improve the interpretation of NES test performance in research studies and clinical evaluations examining central nervous system (CNS) function and neurotoxicant exposure. Performance on a hybrid NES2/3 test battery, consisting of several NES2 and the above listed five NES3 tests, by persons diagnosed with toxicant encephalopathy (TE) was compared to that of controls to determine if performance differences reflect a priori hypothesized brain-behavior relationships. Performance on the NES tests also was correlated with performance on the analogous traditional tests.
Keywords	Brain dysfunction Neurotoxicants Computer-assisted Neuropsychological tests Brain-behavior relationships Exposure Neurobehavioral effects Validation Central nervous system Neurobehavioral evaluation system Test batteries Toxicant encephalopathy
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	Boston Univ., MA. School of Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Rept. for 30 Sep 95-29 Sep 98.
NTIS Issue Number	200320