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Final Study Report on the Developmental Toxicity Evaluation for Benzophenone (CAS No. 119-61-9) Administered by Gavage to Sprague-Dawley (CD (Trade Name)) Rats on Gestational Days 6 through 19.

PB2003101281

Publication Date	2002
Personal Author	Price, C. J.
Page Count	144
Abstract	Benzophenone occurs naturally in some fruits and is used commercially as a perfumery and flavoring ingredient. This study was performed in response to the potential for human explsure and the lack of pertinent developmental toxicity data. Dose selection was based on a screening study in which Sprague-Dawley-derived rats were treated by gavage with benzophenone (0, 25,50, 100,200, or 300 mg/kg body weight/day) on gestational days (gd) 6 through 19 (NTP, 1998b). Maternal toxicity was found at all doses, but evidence of developmental toxicity was limited to a 6-8% decrease for average fetal body weight per litter (not statistically significant) at the high dose.
Keywords	Flavoring ingredients Perfumery ingredients Toxicity Laboratory animals Dosage Concentrations Gavage Rats Kinetics Responses Pregnancy Reproduction(Biology) Benzophenone CAS No. 119-61-9
Source Agency	National Institute of Environmental Health Sciences
Corporate Authors	Research Triangle Inst., Research Triangle Park, NC. Center for Life Sciences and Toxicology.; National Inst. of Environmental Health Sciences, Research Triangle Park,
Supplemental Notes	See also PB2003-101282, Laboratory Supplement and PB2000-106659. Sponsored by National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Document Type	Technical Report
NTIS Issue Number	200305
Contract Number	NTP-N01-ES-65405

Final Study Report on the Developmental Toxicity Evaluation for Benzophenone (CAS No. 119-61-9) Administered by Gavage to Sprague-Dawley (CD (Trade Name)) Rats on Gestational Days 6 through 19.

Final Study Report on the Developmental Toxicity Evaluation for Benzophenone (CAS No. 119-61-9) Administered by Gavage to Sprague-Dawley (CD (Trade Name)) Rats on Gestational Days 6 through 19.
PB2003101281

Publication Date	2002
Personal Author	Price, C. J.
Page Count	144
Abstract	Benzophenone occurs naturally in some fruits and is used commercially as a perfumery and flavoring ingredient. This study was performed in response to the potential for human explsure and the lack of pertinent developmental toxicity data. Dose selection was based on a screening study in which Sprague-Dawley-derived rats were treated by gavage with benzophenone (0, 25,50, 100,200, or 300 mg/kg body weight/day) on gestational days (gd) 6 through 19 (NTP, 1998b). Maternal toxicity was found at all doses, but evidence of developmental toxicity was limited to a 6-8% decrease for average fetal body weight per litter (not statistically significant) at the high dose.
Keywords	Flavoring ingredients Perfumery ingredients Toxicity Laboratory animals Dosage Concentrations Gavage Rats Kinetics Responses Pregnancy Reproduction(Biology) Benzophenone CAS No. 119-61-9
Source Agency	National Institute of Environmental Health Sciences
Corporate Authors	Research Triangle Inst., Research Triangle Park, NC. Center for Life Sciences and Toxicology.; National Inst. of Environmental Health Sciences, Research Triangle Park,
Supplemental Notes	See also PB2003-101282, Laboratory Supplement and PB2000-106659. Sponsored by National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Document Type	Technical Report
NTIS Issue Number	200305
Contract Number	NTP-N01-ES-65405