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Biomarkers of Smoke Exposure Among Firefighters.

PB2002105444

Publication Date	2001
Personal Author	Burgess, J. L.
Page Count	36
Abstract	Firefighters frequently remove their self-contained breathing apparatus during overhaul (seeking and extinguishing hidden fire) despite potentially injurious smoke exposure. Preliminary work demonstrated decline in diffusing capacity (DLCO) associated with number of fires fought, while spirometry, usually the only test of lung function used in firefighter surveillance, remained stable. These findings suggested possible chronic injury due to smoke exposure. We proposed to validate these findings through evaluation of firefighters with biomarkers of lung injury potentially more sensitive to smoke exposure than spirometry, including serum Clara cell protein, alveolar surfactant-associated protein A, radiologically induced sputum tests. The objective of the study was to evaluate smoke exposure during overhaul and sensitive biomarkers of smoke exposure in firefighters.
Keywords	Occupational safety and health Lung function tests Fire fighting Monitoring Spirometry Smoke exposure Firefighters Biomarkers
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	Arizona Univ., Tucson. Coll. of Public Health.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	200217

Biomarkers of Smoke Exposure Among Firefighters.

Biomarkers of Smoke Exposure Among Firefighters.
PB2002105444

Publication Date	2001
Personal Author	Burgess, J. L.
Page Count	36
Abstract	Firefighters frequently remove their self-contained breathing apparatus during overhaul (seeking and extinguishing hidden fire) despite potentially injurious smoke exposure. Preliminary work demonstrated decline in diffusing capacity (DLCO) associated with number of fires fought, while spirometry, usually the only test of lung function used in firefighter surveillance, remained stable. These findings suggested possible chronic injury due to smoke exposure. We proposed to validate these findings through evaluation of firefighters with biomarkers of lung injury potentially more sensitive to smoke exposure than spirometry, including serum Clara cell protein, alveolar surfactant-associated protein A, radiologically induced sputum tests. The objective of the study was to evaluate smoke exposure during overhaul and sensitive biomarkers of smoke exposure in firefighters.
Keywords	Occupational safety and health Lung function tests Fire fighting Monitoring Spirometry Smoke exposure Firefighters Biomarkers
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	Arizona Univ., Tucson. Coll. of Public Health.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	200217