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Developmental Toxicity Evaluation of Formamide (CAS No. 75-12-7) Administered by Gavage to New Zealand White Rabbits on Gestational Days 6 through 29.


PB2001104060

Publication Date 2001
Personal Author George, J. D.; Price, C. J.
Page Count 460
Abstract Formamide (FORM), is a clear, colorless, and odorless liquid that dissolves a variety of materials, is used in organic synthesis reactions, and is used as an experimental cancer treatment. This study was performed due to the potential for human exposure to FORM and the lack of complete developmental toxicity data. Dose selection was based on a developmental toxicity screen in New Zealand White rabbits (NTP, 1998c). Naturally-mated female New Zealand White (NZW) rabbits were dosed by gavage with FORM (10, 20, 40, 80 or 120 mg/kg body weight/day) or its vehicle (deionized/distilled water) on gestational days (gd) 6 through 29. Mile maternal toxicity and abortion or early delivery in 3/7 pregnancies were found at 120 mg/kg/day. Although not statistically significant, the reduction in average fetal body weight at the high dose (83% of control weight) was considered to be a biologically relevant response to FORM exposure.
Keywords
  • Toxicity
  • Formamide
  • Rabbits
  • Pregnancy
  • Laboratory animals
  • Solvents
  • Dosage
  • Gavage
  • Ingestion
  • CAS No 75-12-7
Source Agency
  • National Institute of Environmental Health Sciences
Corporate Authors Research Triangle Inst., Research Triangle Park, NC. Center for Life Sciences and Toxicology.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes See also PB99-139701. Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type Technical Report
Title Note Final rept.
NTIS Issue Number 200113
Contract Number
  • NTP/NIEHS-N01-ES-65405
Developmental Toxicity Evaluation of Formamide (CAS No. 75-12-7) Administered by Gavage to New Zealand White Rabbits on Gestational Days 6 through 29.
Developmental Toxicity Evaluation of Formamide (CAS No. 75-12-7) Administered by Gavage to New Zealand White Rabbits on Gestational Days 6 through 29.
PB2001104060

  • Toxicity
  • Formamide
  • Rabbits
  • Pregnancy
  • Laboratory animals
  • Solvents
  • Dosage
  • Gavage
  • Ingestion
  • CAS No 75-12-7
  • National Institute of Environmental Health Sciences
  • NTP/NIEHS-N01-ES-65405
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