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Case Control Study of Multiple Myeloma Among workers Exposed to Ionizing Radiatio and Other Physical and Chemical Agents.

PB2001101675

Publication Date	1998
Page Count	232
Abstract	The National Institute for Occupational Safety and Health (NIOSH) contracted with the University of North Carolina to conduct a case-control study of multiple myeloma among workers at Department of Energy nuclear facilities. The basic design and data to be used for the study were specified by NIOSH. The overall objective of this research was to evaluate occupational exposures to ionizing radiation and other biological, physical and chemical hazards as risk factors for multiple myeloma. Although increased rates of multiple myeloma and other hematological malignancies have been observed in relation to higher doses of ionizing radiation among A-bomb survivors and some medically exposed groups (BEIR V, 1990), epidemiological studies of low dose, low dose rate exposures in the range encountered in occupational settings are less clear, although suggestive of an increased risk. The ambiguity of results of such studies derives from the low magnitude of potential excess risks to be detected at low doses, the rareness of the disease, difficulties in correctly classifying worker exposures over long time periods, and the potential for confounding or modifying effects of other occupational exposures.
Keywords	Malignant neoplasms Occupational exposures Chemical hazards Ionizing radiation Risk factors Physical agents Chemical agents Employees Epidemiology Data collection Multiple myeloma Nuclear facilities Department of Energy
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	North Carolina Univ. at Chapel Hill. Dept. of Epidemiology.; National Inst. for Occupational Safety and Health, Rockville, MD.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type	Technical Report
Title Note	Technial rept. (Final).
NTIS Issue Number	200105

Case Control Study of Multiple Myeloma Among workers Exposed to Ionizing Radiatio and Other Physical and Chemical Agents.

Case Control Study of Multiple Myeloma Among workers Exposed to Ionizing Radiatio and Other Physical and Chemical Agents.
PB2001101675

Publication Date	1998
Page Count	232
Abstract	The National Institute for Occupational Safety and Health (NIOSH) contracted with the University of North Carolina to conduct a case-control study of multiple myeloma among workers at Department of Energy nuclear facilities. The basic design and data to be used for the study were specified by NIOSH. The overall objective of this research was to evaluate occupational exposures to ionizing radiation and other biological, physical and chemical hazards as risk factors for multiple myeloma. Although increased rates of multiple myeloma and other hematological malignancies have been observed in relation to higher doses of ionizing radiation among A-bomb survivors and some medically exposed groups (BEIR V, 1990), epidemiological studies of low dose, low dose rate exposures in the range encountered in occupational settings are less clear, although suggestive of an increased risk. The ambiguity of results of such studies derives from the low magnitude of potential excess risks to be detected at low doses, the rareness of the disease, difficulties in correctly classifying worker exposures over long time periods, and the potential for confounding or modifying effects of other occupational exposures.
Keywords	Malignant neoplasms Occupational exposures Chemical hazards Ionizing radiation Risk factors Physical agents Chemical agents Employees Epidemiology Data collection Multiple myeloma Nuclear facilities Department of Energy
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	North Carolina Univ. at Chapel Hill. Dept. of Epidemiology.; National Inst. for Occupational Safety and Health, Rockville, MD.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type	Technical Report
Title Note	Technial rept. (Final).
NTIS Issue Number	200105