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Study of the Feasibility of Research on Pathologic Types of Lung Cancer in Silica- and Radon-Exposed Miners, Final Report.

PB2001101410

Publication Date	2000
Personal Author	Jacobsen, M.; Ducatman, B.; Cox-Ganser, J.
Page Count	66
Abstract	The aim of this report was to determine whether post mortem materials stored in a large German autopsy archive could be used for research on how exposure to silica dust, or the presence of silicosis, influences pathologic characteristics of lung cancer in humans. The sample collected was selected from all those potentially available so as to generate as wide a range as possible of exposures to silica dust and to ionizing radiation. Estimates of cumulative exposures to silica, radon, arsenic, and asbestos were correlated. The patterns of joint distributions of occupational exposures suggest that appropriate further sampling from the autopsy archive can provide data that could be used to test the underlying research hypothesis.
Keywords	Occupational safety and health Silica dusts Radon Lung cancer Mining industry Germany Autopsy Research Exposure(Physiology) Lungs Ionizing radiation Arsenic Asbestos Hypothesis testing Epidemiology Occupational exposures Indoor air pollution Risk assessments Feasibility studies Respiratory system disorders Silicosis
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	West Virginia Univ., Morgantown.; National Cancer Inst., Bethesda, MD.; National Inst. for Occupational Safety and Health, Rockville, MD.; Bergbau-Berufsgenossenschaft, Bochum, (Germany).
Supplemental Notes	Prepared in cooperation with Bergbau-Berufsgenossenschaft, Bochum, (Germany). Sponsored by National Inst. for Occupational Safety and Health, Rockville, MD. and National Cancer Inst., Bethesda, MD.
Document Type	Technical Report
NTIS Issue Number	200104

Study of the Feasibility of Research on Pathologic Types of Lung Cancer in Silica- and Radon-Exposed Miners, Final Report.

Study of the Feasibility of Research on Pathologic Types of Lung Cancer in Silica- and Radon-Exposed Miners, Final Report.
PB2001101410

Publication Date	2000
Personal Author	Jacobsen, M.; Ducatman, B.; Cox-Ganser, J.
Page Count	66
Abstract	The aim of this report was to determine whether post mortem materials stored in a large German autopsy archive could be used for research on how exposure to silica dust, or the presence of silicosis, influences pathologic characteristics of lung cancer in humans. The sample collected was selected from all those potentially available so as to generate as wide a range as possible of exposures to silica dust and to ionizing radiation. Estimates of cumulative exposures to silica, radon, arsenic, and asbestos were correlated. The patterns of joint distributions of occupational exposures suggest that appropriate further sampling from the autopsy archive can provide data that could be used to test the underlying research hypothesis.
Keywords	Occupational safety and health Silica dusts Radon Lung cancer Mining industry Germany Autopsy Research Exposure(Physiology) Lungs Ionizing radiation Arsenic Asbestos Hypothesis testing Epidemiology Occupational exposures Indoor air pollution Risk assessments Feasibility studies Respiratory system disorders Silicosis
Source Agency	National Institute for Occupational Safety and Health
Corporate Authors	West Virginia Univ., Morgantown.; National Cancer Inst., Bethesda, MD.; National Inst. for Occupational Safety and Health, Rockville, MD.; Bergbau-Berufsgenossenschaft, Bochum, (Germany).
Supplemental Notes	Prepared in cooperation with Bergbau-Berufsgenossenschaft, Bochum, (Germany). Sponsored by National Inst. for Occupational Safety and Health, Rockville, MD. and National Cancer Inst., Bethesda, MD.
Document Type	Technical Report
NTIS Issue Number	200104