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A Toxico-Pathologic Study of Phosgene Oxime.

PB168119

Publication Date	1965
Personal Author	McAdams, A. J.; Joffe, M. H.
Page Count	28
Abstract	The local lesion produced by aqueous dilutions of phosgene oxime applied cutaneously and intradermally have been described. They may be considered as corrosive type lesions, the course being that usually seen with escharotics. The clinical-pathological features of the pulmonary edema produced by phosgene oxime are described. The relationship of concentration of solution and area of contact between skin and agent with respect to manifestation of systemic toxicity were investigated. Systemic toxic signs are correlated directly with concentration of solution used and inversely with area exposed. The mechanism of toxic action of phosgene oxime and phosgene gas are considered. Reasons are given for believing that the local action of both is of a physicochemical nature. The reasons for the production of massive pulmonary edema as a consequence of cutaneous or intravenous administration of phosgene oxime are unclear. (Author)
Keywords	Phosgene Toxicity Oximes Poisoning Skin Edema Lungs Tissues(Biology) Wounds + injuries Histological techniques Pathology Poisonous gases Chemical warfare agents Dosage Guinea pigs Humans Lesions
NTIS Subject Category	57Y - Toxicology 74D - Chemical, Biological, & Radiological Warfare
Corporate Authors	Chemical Corps Medical Labs., Army Chemical Center, MD.
Supplemental Notes	Declassified 19 Oct 60.
Document Type	Technical Report
Title Note	Research rept.
NTIS Issue Number	196401

A Toxico-Pathologic Study of Phosgene Oxime.

A Toxico-Pathologic Study of Phosgene Oxime.
PB168119

Publication Date	1965
Personal Author	McAdams, A. J.; Joffe, M. H.
Page Count	28
Abstract	The local lesion produced by aqueous dilutions of phosgene oxime applied cutaneously and intradermally have been described. They may be considered as corrosive type lesions, the course being that usually seen with escharotics. The clinical-pathological features of the pulmonary edema produced by phosgene oxime are described. The relationship of concentration of solution and area of contact between skin and agent with respect to manifestation of systemic toxicity were investigated. Systemic toxic signs are correlated directly with concentration of solution used and inversely with area exposed. The mechanism of toxic action of phosgene oxime and phosgene gas are considered. Reasons are given for believing that the local action of both is of a physicochemical nature. The reasons for the production of massive pulmonary edema as a consequence of cutaneous or intravenous administration of phosgene oxime are unclear. (Author)
Keywords	Phosgene Toxicity Oximes Poisoning Skin Edema Lungs Tissues(Biology) Wounds + injuries Histological techniques Pathology Poisonous gases Chemical warfare agents Dosage Guinea pigs Humans Lesions
NTIS Subject Category	57Y - Toxicology 74D - Chemical, Biological, & Radiological Warfare
Corporate Authors	Chemical Corps Medical Labs., Army Chemical Center, MD.
Supplemental Notes	Declassified 19 Oct 60.
Document Type	Technical Report
Title Note	Research rept.
NTIS Issue Number	196401