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Initial Submission: Ina-7881 Developmental Toxicity Study in Rats Dosed by Gavage on Days 7-16 of Gestation (final Report) with Attachments and Cover Letter dated 032792.

OTS0535905

Publication Date	1992
Page Count	204
Abstract	Benzoic acid, (2-[[[[(4-ethoxy-6- methylamino-1,3,-5-triazin-2-yl)amino]carbonyl]amino]sulfonyl]-,methyl ester) (CAS# 97780-06-8) was evaluated for maternal and developmental toxicity. The test substance was administered by oral gavage to 25 rats (CD BR strain) per group at doses of 0, 60, 250, 1000, and 4000 mg/Kg/day on days 7 through 16 of gestation. Among the dams there were no treatment related mortalities or clinical abnormalities during this study. The high dose group exhibited reduced body weight gain and decreased feed consumption. No pathological changes were noted in any groups at postmortem and no differences in liver weights were observed. No adverse effects on reproductive parameters or differences in mean fetal weights were observed. No significant differences were observed in rates of malformations or developmental variation for any treatment group as compared to controls. The percentage of fetuses per litter with variations due to retarded development in the high dose group was significantly higher than controls. The NOEL reported for this study for the dams and fetuses was 1000 mg/Kg/day.
Keywords	Toxicology Health effects E i dupont de nemours & co Toxic substances Ina-7881 Laboratory animals Reproduction/fertility effects Teratogenicity Mammals Rats Oral Gavage CAS No. 97780-06-8
Source Agency	Office of Toxic Substances
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 99 - Chemistry 44G - Environmental & Occupational Factors
Corporate Authors	Environmental Protection Agency, Washington, DC. Office of Toxic
Document Type	Technical Report
NTIS Issue Number	200820

Initial Submission: Ina-7881 Developmental Toxicity Study in Rats Dosed by Gavage on Days 7-16 of Gestation (final Report) with Attachments and Cover Letter dated 032792.

Initial Submission: Ina-7881 Developmental Toxicity Study in Rats Dosed by Gavage on Days 7-16 of Gestation (final Report) with Attachments and Cover Letter dated 032792.
OTS0535905

Publication Date	1992
Page Count	204
Abstract	Benzoic acid, (2-[[[[(4-ethoxy-6- methylamino-1,3,-5-triazin-2-yl)amino]carbonyl]amino]sulfonyl]-,methyl ester) (CAS# 97780-06-8) was evaluated for maternal and developmental toxicity. The test substance was administered by oral gavage to 25 rats (CD BR strain) per group at doses of 0, 60, 250, 1000, and 4000 mg/Kg/day on days 7 through 16 of gestation. Among the dams there were no treatment related mortalities or clinical abnormalities during this study. The high dose group exhibited reduced body weight gain and decreased feed consumption. No pathological changes were noted in any groups at postmortem and no differences in liver weights were observed. No adverse effects on reproductive parameters or differences in mean fetal weights were observed. No significant differences were observed in rates of malformations or developmental variation for any treatment group as compared to controls. The percentage of fetuses per litter with variations due to retarded development in the high dose group was significantly higher than controls. The NOEL reported for this study for the dams and fetuses was 1000 mg/Kg/day.
Keywords	Toxicology Health effects E i dupont de nemours & co Toxic substances Ina-7881 Laboratory animals Reproduction/fertility effects Teratogenicity Mammals Rats Oral Gavage CAS No. 97780-06-8
Source Agency	Office of Toxic Substances
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 99 - Chemistry 44G - Environmental & Occupational Factors
Corporate Authors	Environmental Protection Agency, Washington, DC. Office of Toxic
Document Type	Technical Report
NTIS Issue Number	200820