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Oral Toxicity in Rats Test Results with Cover Letter Dated 12/17/1982.

OTS0514286

Publication Date	1982
Page Count	6
Abstract	Acute oral toxicity was evaluated in groups of 10 male Wistar rats administered single doses of 98% pseudocumene by oral gavage at levels of 3.51, 5.0, 7.12 and 10.14 g/kg of body weight. Mortality was observed in 3 animals in the 5.0 g/kg dose group, 7 in the 7.12 g/kg dose group, and all 10 in the highest dose group. The LD50 value was calculated to be 6.0 g/kg of body weight, with confidence limits of 4.92 - 7.32 g/kg, by the Litchfield and Wilcoxon method. Clinical observations included lethargy, ptosis, ataxia, and piloerection. Gross necropsy findings were not reported.
Keywords	Toxicology Health effects 1,2,4-trimethylbenzene Acute Toxicity Mammals Rats Oral Gavage Toxic substances Laboratory animals CAS No. 95-63-6
Source Agency	Office of Toxic Substances
Corporate Authors	Mb Research Laboratories, Inc.; Environmental Protection Agency, Washington, DC. Office of Toxic
Supplemental Notes	The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Document Type	Technical Report
NTIS Issue Number	200822

Oral Toxicity in Rats Test Results with Cover Letter Dated 12/17/1982.

Oral Toxicity in Rats Test Results with Cover Letter Dated 12/17/1982.
OTS0514286

Publication Date	1982
Page Count	6
Abstract	Acute oral toxicity was evaluated in groups of 10 male Wistar rats administered single doses of 98% pseudocumene by oral gavage at levels of 3.51, 5.0, 7.12 and 10.14 g/kg of body weight. Mortality was observed in 3 animals in the 5.0 g/kg dose group, 7 in the 7.12 g/kg dose group, and all 10 in the highest dose group. The LD50 value was calculated to be 6.0 g/kg of body weight, with confidence limits of 4.92 - 7.32 g/kg, by the Litchfield and Wilcoxon method. Clinical observations included lethargy, ptosis, ataxia, and piloerection. Gross necropsy findings were not reported.
Keywords	Toxicology Health effects 1,2,4-trimethylbenzene Acute Toxicity Mammals Rats Oral Gavage Toxic substances Laboratory animals CAS No. 95-63-6
Source Agency	Office of Toxic Substances
Corporate Authors	Mb Research Laboratories, Inc.; Environmental Protection Agency, Washington, DC. Office of Toxic
Supplemental Notes	The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Document Type	Technical Report
NTIS Issue Number	200822