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OTS0513957

Publication Date	1987
Page Count	53
Abstract	Dermal carcinogenicity was evaluated in groups of male and female CF1 mice (50/sex/group) receiving applications (volume not reported) of 0.05% or 0.2% (based on preliminary studies) 1,4-butanediol diglycidyl ether in acetone twice weekly to the dorsal skin for 103 weeks. Of all animals in both dose groups, 5 animals developed 6 neoplasms of the skin and subcutis; 1 control animal developed a tumor. A transient irritant reaction was observed in 37 animals with no thickening of the epidermis. A statistically significant increase in neoplasms of the treated skin was not observed.
Keywords	Toxicology Health effects 1,4-butane Diol (2425-79-8) Chronic Toxicity Carcinogenicity Mammals Mice Dermal Toxic substances Laboratory animals CAS No. 2425-79-8
Source Agency	Office of Toxic Substances
Corporate Authors	CIBA-GEIGY Corp., Ardsley, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic
Supplemental Notes	The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Document Type	Technical Report
NTIS Issue Number	200822

Cutaneous Carcinogenicity Study with Mice on the Diglycidyl Ether of 1,4-butane Diol with Attachments and Cover Letter dated 09/28/1987.

Cutaneous Carcinogenicity Study with Mice on the Diglycidyl Ether of 1,4-butane Diol with Attachments and Cover Letter dated 09/28/1987.
OTS0513957

Publication Date	1987
Page Count	53
Abstract	Dermal carcinogenicity was evaluated in groups of male and female CF1 mice (50/sex/group) receiving applications (volume not reported) of 0.05% or 0.2% (based on preliminary studies) 1,4-butanediol diglycidyl ether in acetone twice weekly to the dorsal skin for 103 weeks. Of all animals in both dose groups, 5 animals developed 6 neoplasms of the skin and subcutis; 1 control animal developed a tumor. A transient irritant reaction was observed in 37 animals with no thickening of the epidermis. A statistically significant increase in neoplasms of the treated skin was not observed.
Keywords	Toxicology Health effects 1,4-butane Diol (2425-79-8) Chronic Toxicity Carcinogenicity Mammals Mice Dermal Toxic substances Laboratory animals CAS No. 2425-79-8
Source Agency	Office of Toxic Substances
Corporate Authors	CIBA-GEIGY Corp., Ardsley, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic
Supplemental Notes	The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Document Type	Technical Report
NTIS Issue Number	200822