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Developmental Toxicity Study in Rabbits Using Test Article 5601-56-1.

OTS0513641

Publication Date	2000
Page Count	42
Abstract	Teratogenicity of test substance 5601-56-1 (Naphthalene) was evaluated in 4 groups of 18 New Zealand White rabbits dosed 0, 40, 200, and 400 mg/kg/day by gavage gestation days (GD) 6-18. Maternal weight gain was not significantly reduced in any dose group. Food consumption decreased significantly in high dose group GD 7-15, but increased GD 23-25 and 27-29. No compound-related maternal mortalities were reported. At 40 mg/kg, 2 does aborted and 1 delivered prematurely (GD 29). Dose related effects on does were excessive facial grooming, decreased activity, dyspnea, infrequent loose stools or diarrhea, salivation, nasal and ocular discharge, body drop, and cyanosis. No significant differences were ob- served between treated and control groups in total number of implantations, corpora lutea, viable and non-viable fetuses, fetal sex distribution and post- implantational losses (early and late resorptions). Uterine weights were not reported. The 9 fetal deaths on Caesarean delivery GD 29 were judged coincid- ental since fetal physical characteristics were not dose-related. Fetal mal- formations were considered spontaneous. In the high dose group, a significant decrease in the number of 13th right-sided ribs was reported secondary to the total number of 13th paired ribs observed. Statistical differences were deter- mined by one-way analysis of variance.
Keywords	Toxicology Health effects Naphthalene (91-20-3) Reproduction/fertility Effects Teratogenicity Mammals Rabbits Oral Gavage Toxic substances Laboratory animals CAS No. 91-20-3
Source Agency	Office of Toxic Substances
Corporate Authors	Pharmakon Research International, Inc., Waverly, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic
Supplemental Notes	The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Document Type	Technical Report
NTIS Issue Number	200822

Developmental Toxicity Study in Rabbits Using Test Article 5601-56-1.

Developmental Toxicity Study in Rabbits Using Test Article 5601-56-1.
OTS0513641

Publication Date	2000
Page Count	42
Abstract	Teratogenicity of test substance 5601-56-1 (Naphthalene) was evaluated in 4 groups of 18 New Zealand White rabbits dosed 0, 40, 200, and 400 mg/kg/day by gavage gestation days (GD) 6-18. Maternal weight gain was not significantly reduced in any dose group. Food consumption decreased significantly in high dose group GD 7-15, but increased GD 23-25 and 27-29. No compound-related maternal mortalities were reported. At 40 mg/kg, 2 does aborted and 1 delivered prematurely (GD 29). Dose related effects on does were excessive facial grooming, decreased activity, dyspnea, infrequent loose stools or diarrhea, salivation, nasal and ocular discharge, body drop, and cyanosis. No significant differences were ob- served between treated and control groups in total number of implantations, corpora lutea, viable and non-viable fetuses, fetal sex distribution and post- implantational losses (early and late resorptions). Uterine weights were not reported. The 9 fetal deaths on Caesarean delivery GD 29 were judged coincid- ental since fetal physical characteristics were not dose-related. Fetal mal- formations were considered spontaneous. In the high dose group, a significant decrease in the number of 13th right-sided ribs was reported secondary to the total number of 13th paired ribs observed. Statistical differences were deter- mined by one-way analysis of variance.
Keywords	Toxicology Health effects Naphthalene (91-20-3) Reproduction/fertility Effects Teratogenicity Mammals Rabbits Oral Gavage Toxic substances Laboratory animals CAS No. 91-20-3
Source Agency	Office of Toxic Substances
Corporate Authors	Pharmakon Research International, Inc., Waverly, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic
Supplemental Notes	The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Document Type	Technical Report
NTIS Issue Number	200822