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14-day Subchronic Toxicity Study in Rats with 2-butenal.

OTS0510394

Publication Date	1986
Page Count	28
Abstract	In a subchronic toxicity study, male and female Sprague-Dawley rats (5/sex/group) were fed diets containing crotonaldehyde at dose nominal dose levels of 0, 22, 44, 88 or 175 mg/kg/day for 14 days. Actual mean dosages (male/female) for the above groups were: 0/0, 19/17, 36/36, 73/68, and 139/136 mg/kg/day, respectively. There were no statistically significant differences between treated and control animals in the following: mortality, clinical signs of toxicity, body weight, food consumption, efficiency of food utilization (change in body weight/weekly food consumption), and absolute or relative organ weights. There were no exposure-related gross lesions observed in any of the treated groups.
Keywords	Toxicology Health effects 2-butenal (4170-30-3) Subchronic Toxicity Mammals Rats Oral Diet Toxic substances Laboratory animals CAS No. 4170-30-3
Source Agency	Office of Toxic Substances
Corporate Authors	Borriston Labs., Inc., Temple Hills, MD.; Environmental Protection Agency, Washington, DC. Office of Toxic
Supplemental Notes	The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Document Type	Technical Report
NTIS Issue Number	200822

14-day Subchronic Toxicity Study in Rats with 2-butenal.

14-day Subchronic Toxicity Study in Rats with 2-butenal.
OTS0510394

Publication Date	1986
Page Count	28
Abstract	In a subchronic toxicity study, male and female Sprague-Dawley rats (5/sex/group) were fed diets containing crotonaldehyde at dose nominal dose levels of 0, 22, 44, 88 or 175 mg/kg/day for 14 days. Actual mean dosages (male/female) for the above groups were: 0/0, 19/17, 36/36, 73/68, and 139/136 mg/kg/day, respectively. There were no statistically significant differences between treated and control animals in the following: mortality, clinical signs of toxicity, body weight, food consumption, efficiency of food utilization (change in body weight/weekly food consumption), and absolute or relative organ weights. There were no exposure-related gross lesions observed in any of the treated groups.
Keywords	Toxicology Health effects 2-butenal (4170-30-3) Subchronic Toxicity Mammals Rats Oral Diet Toxic substances Laboratory animals CAS No. 4170-30-3
Source Agency	Office of Toxic Substances
Corporate Authors	Borriston Labs., Inc., Temple Hills, MD.; Environmental Protection Agency, Washington, DC. Office of Toxic
Supplemental Notes	The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Document Type	Technical Report
NTIS Issue Number	200822