| Abstract |
The ability of 2-mercapto- benzothiazole to induce specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cells (Mouse Lymphoma Forward Mutation Assay) was evaluated in the presence and absence of Aroclor-induced rat liver S9 fraction to provide metabolic activation. Based on preliminary cytotoxicity tests, 4 trials were performed in the absence of activation at concentrations ranging from 1.56 - 100.0 ug/ml producing cell survivals realtive to the solvent control (DMSO) of 73.5 - 18.6%. In the presence of activation, 4 trials were performed using the same concentration range and producing relative cell survivals of 112.3 - 5.8%. A repeatable significant increase in the mutation frequency was not observed in either the activated or nonactivated trials. The mutagenicity of 2-mercaptobenzothiazole was evaluated in Salmonella tester strains TA1535, TA1537, TA1538, TA98 and TA100, and the yeast Saccharomyces cerevisiae D4, both in the presence and absence of Aroclor-induced rat liver S9 fraction to provide metabolic activation. After bacterial toxicity determinations, 2-mercaptobenzothiazole was tested for mutagenicity at concentrations of 0.1, 1.0, 10, 100, and 500 ug/plate using the plate overlay method. 2-Mercaptobenzothiazole did not induce a positive repsonse in any of the tester strains, either with or without metabolic activation. Mutagenicity Evaluation of Thiotax Bo-78-240 in the Mouse Lymphoma Forward Mutation Assay. Mercaptobenzothiazole Soil Absorption Study with Attachments. Identification of Hydrolysis Products for Thiotax Accelerator under Simulated Environmental and Physiological Conditions with Cover Letter. 2-mercaptobenzothiazole Environmental Monitoring with Attachments. Acute (96-hour) Toxicity of Thiotax to Rainbow Trout and Bluegill. Acute Toxicity of Thiotax (ab-79-1384365-1d) to Daphnia Magna. Toxicity of Thiotax (bn-79-1384365-1e) to the Freshwater Alga Selenastrum Capricornutum. Acute Toxicity of Thiotax (ab-79-1384365-1a) to Fathead Minnows (pimephales Promelas). Toxicological Investigations of 2-mercaptobenzothiazole (thiotax). Toxicologic Investigation Of: Thiotax Mbt. Evaluation of Potential Hazards by Dermal Contact. Toxicologic Investigation Of: Thiotax Powder with Attached Memo. Mutagenicity Evaluation of Bio-76-177 Cp1975 Thiotax Final Report. Time-independent Toxicity Study on Thiotax Using Rainbow Trout as the Test Organism. Toxicologic Investigation Of: Radax. Evaluation of Potential Hazards by Dermal Contact. Toxicologic Investigation Of: Ureka White. Selected Environmental Fate Studies on Nine Chemical Compounds. Photodegradation Screening in an Aqueous Environment. Thiofide Hydrolysis with Cover Memo. Acute Toxicity of Nambt 50% (ab-78-1384320-3a) to Daphnia Magna. Acute (96-hour) Toxicity of Nambt-50% to Rainbow Trout and Bluegill. Acute Toxicity of Na-mbt 50% (bn-78-1384320) to the Freshwater Alga Selenastrum Capricornutum. Mutagenicity Evaluation of Bio-76-176 Cp1601 Nambt-50%. Toxicologic Investigation of Sodium Mbt-50%. Toxicity Studies On: Sodium Mbt Solution-22%. Water Solubility and Octanol/water Partition Coefficient of Selected Rubber Chemicals. Toxicity Studies on Cp 01601. Toxicologic Investigation Of: Bantex. Mutagenicity Evaluation of Bio-77-104 Bantex Erl/20389/19. |
