| Abstract |
The mutagenicity of dichloromethane was evaluated in Salmonella bacterial tester strains TA98, TA100, TA1535, TA1537, and TA1538 and Saccharomyces cerevisiae yeast strain D4, both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Dichloromethane was tested at concentrations of 0.1, 1, 5, and 10 ul/plate using the plate incorporation method. Dichloromethane did not cause a reproducible positive response in any of the bacterial or yeast tester strains, either with or without metabolic activation. Due to the volatility of the test material, separate tests under an inverted and sealed petri dish, both in the presence and absence of metabolic activation, were conducted using Salmonella tester strains TA98 and TA100. Dichloromethane at a concentration of 0.05 ml/inverted petri dish did not cause a reproducible positive response either with or without metabolic activation. Characterization & Fate of the Discharge of Priority Pollutants from the Rohm & Haas Philadelphia Plant into the Delaware low Level Collector of the Philadelphia Sewer. |
